Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, Egypt.
Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Nat Prod Res. 2022 Feb;36(3):828-836. doi: 10.1080/14786419.2020.1800693. Epub 2020 Jul 29.
New cycloartane-type triterpene 23 /-3-hydroxycycloart-24-ene-23-methyl ether (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of L. (Euphorbiaceae). The known compounds (-) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids. The new compound was elucidated by comprehensive 1 D & 2 D NMR experiments as well as LR & HR-FAB-MS. In addition, the isolated cycloartane-type triterpenoids have been tested for cytotoxicity against different cell lines. The new compound exhibited good to weak selective cytotoxic activities against HepG2, Huh-7, KLM-1, 1321N1 and HeLa cell lines with IC values of 20.67 ± 0.72, 16.24 ± 0.53, 22.59 ± 0.94, 25.99 ± 0.31 and 40.50 ± 3.14 μM, respectively.
从大戟科植物柳叶菜属（L.）的地上部分分离得到一种新的环阿尔廷型三萜 23 /-3-羟基环阿尔廷-24-烯-23-甲醚（作为 C-23 差向异构体混合物）和 10 种已知化合物，包括 1 种甾体、3 种脂肪酸和 6 种三萜。通过 1D 和 2D-NMR 光谱以及与文献报道的数据进行比较，并通过 GC-MS 对分离出的脂肪酸进行鉴定，确定了已知化合物的结构。通过全面的 1D 和 2D NMR 实验以及 LR 和 HR-FAB-MS 确定了新化合物的结构。此外，分离得到的环阿尔廷型三萜对不同细胞系的细胞毒性进行了测试。新化合物 对 HepG2、Huh-7、KLM-1、1321N1 和 HeLa 细胞系表现出良好到弱的选择性细胞毒性，IC 值分别为 20.67 ± 0.72、16.24 ± 0.53、22.59 ± 0.94、25.99 ± 0.31 和 40.50 ± 3.14 μM。
