Jiménez-González Víctor, Kowalczyk Tomasz, Piekarski Janusz, Szemraj Janusz, Rijo Patricia, Sitarek Przemysław
Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Cancers (Basel). 2023 Dec 25;16(1):114. doi: 10.3390/cancers16010114.
The number of cancer cases will reach 24 million in 2040, according to the International Agency for Research on Cancer. Current treatments for cancer are not effective and selective for most patients; for this reason, new anticancer drugs need to be developed and researched enough. There are potentially useful drugs for cancer isolated from plants that are being used in the clinic. Available information about phytochemistry, traditional uses, in vitro and in vivo experiments with plants, and pure compounds isolated from the Euphorbiaceae family indicates that this family of plants has the potential to develop anticancer drugs. This review examines selected species from the Euphorbiaceae family and their bioactive compounds that could have potential against different types of cancer cells. It reviews the activity of crude extracts, isolated compounds, and nanoparticles and the potential underlying mechanisms of action.
根据国际癌症研究机构的数据，到2040年癌症病例数将达到2400万。目前的癌症治疗方法对大多数患者而言既无效也缺乏选择性；因此，需要充分研发和研究新型抗癌药物。从植物中分离出的一些潜在有用的抗癌药物已应用于临床。有关大戟科植物的植物化学、传统用途、体外和体内实验以及从中分离出的纯化合物的现有信息表明，该科植物具有开发抗癌药物的潜力。本综述研究了大戟科选定的物种及其对不同类型癌细胞可能具有潜在活性的生物活性化合物。它回顾了粗提物、分离化合物和纳米颗粒的活性以及潜在的作用机制。
