Easley Alexandra D, Monroe Mary Beth Browning, Hasan Sayyeda M, Weems Andrew C, Frederick Jane, Maitland Duncan J
Biomedical Device Laboratory, Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843-3120.
J Appl Polym Sci. 2019 Apr 10;136(14). doi: 10.1002/app.47268. Epub 2018 Dec 12.
Current vascular aneurysm treatments often require either highly invasive strategy to surgically occlude an aneurysm or endovascular occlusion via metal coils. While endovascular coils are safer, they have limited efficacy. Endovascular coils that are integrated with shape memory polymer (SMP) foams have the potential to improve occlusion and reduce coil risks; however, the mechanical performance and limited homogeneity of SMP foams can hinder their effective use. To address this issue, SMP foams are synthesized using the monomer diethanolamine (DEA) in place of triethanolamine (TEA) to provide improved mechanical properties for medical device applications. Mechanical testing and micro-fracture analysis were performed on DEA and TEA foams. DEA foams show improved toughness and reduced micro-fractures compared to the control. This work presents the utility of DEA in SMP synthesis to enable the potential production of safer aneurysm treatment.
当前的血管动脉瘤治疗通常需要采用高度侵入性的策略来手术封堵动脉瘤，或者通过金属线圈进行血管内封堵。虽然血管内线圈更安全，但它们的疗效有限。与形状记忆聚合物（SMP）泡沫集成的血管内线圈有改善封堵效果并降低线圈风险的潜力；然而，SMP泡沫的机械性能和有限的均匀性会阻碍其有效应用。为了解决这个问题，使用单体二乙醇胺（DEA）代替三乙醇胺（TEA）合成SMP泡沫，以提供用于医疗设备应用的改进机械性能。对DEA和TEA泡沫进行了力学测试和微裂缝分析。与对照组相比，DEA泡沫显示出更高的韧性和更少的微裂缝。这项工作展示了DEA在SMP合成中的效用，以实现更安全的动脉瘤治疗的潜在生产。
