Han Deqiang, Zheng Xin, Wang Xueyao, Jin Tao, Cui Li, Chen Zhiguo
Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, And Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China.
Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China.
Stem Cells Int. 2020 Jul 7;2020:8838046. doi: 10.1155/2020/8838046. eCollection 2020.
Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be derived from various tissues. Due to their regenerative and immunomodulatory properties, MSCs have been extensively researched and tested for treatment of different diseases/indications. One mechanism that MSCs exert functions is through the transfer of mitochondria, a key player involved in many biological processes in health and disease. Mitochondria transfer is bidirectional and has an impact on both donor and recipient cells. In this review, we discussed how MSC-mediated mitochondrial transfer may affect cellular metabolism, survival, proliferation, and differentiation; how this process influences inflammatory processes; and what is the molecular machinery that mediates mitochondrial transfer. In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.
间充质干/基质细胞（MSCs）是可源自各种组织的多能干细胞。由于其再生和免疫调节特性，MSCs已被广泛研究并测试用于治疗不同疾病/适应症。MSCs发挥功能的一种机制是通过线粒体转移，线粒体是健康和疾病中许多生物过程的关键参与者。线粒体转移是双向的，对供体细胞和受体细胞都有影响。在本综述中，我们讨论了MSC介导的线粒体转移如何影响细胞代谢、存活、增殖和分化；该过程如何影响炎症过程；以及介导线粒体转移的分子机制是什么。最后，我们总结了通过应用MSCs和/或MSC衍生的线粒体治疗中风和脊髓损伤的临床前研究和临床试验的最新进展。
