Ren Hui, Shen Zhipeng, Shen Jirui, Zhang Yu, Zhang Yunhua
Department of Ultrasound, Liaocheng Third People's Hospital, Liaocheng, Shandong 252000, P.R. China.
Department of Ultrasound, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
Oncol Lett. 2020 Aug;20(2):1028-1032. doi: 10.3892/ol.2020.11676. Epub 2020 May 28.
Diagnostic value of Doppler ultrasound parameters combined with matrix metalloproteinase-11 (MMP-11) in early breast cancer and benign breast diseases were investigated. A total of 72 patients who underwent color Doppler ultrasound examination in Liaocheng Third People's Hospital from March 2015 to August 2018 were collected as research subjects, and the blood of 60 healthy subjects who underwent physical examinations was collected. The expression level of MMP-11 in serum of breast cancer patients was evaluated, and the diagnostic value of color Doppler ultrasound combined with MMP-11 in breast cancer was assessed. The diagnostic results of color Doppler ultrasound and the imaging characteristics of breast cancer patients were recorded. The results of biopsy and ultrasound were compared. The expression level of MMP-11 in serum of breast cancer patients was significantly higher than that of healthy subjects (P<0.05). The AUC of MMP-11 was 0.735, the sensitivity was 66.67%, and the specificity was 86.11%. Among the 72 patients, there were 41 patients diagnosed with breast cancer by serum MMP-11 examination, 38 patients diagnosed by ultrasound examination, 33 patients diagnosed by combined diagnosis, and 30 patients diagnosed by pathology biopsy. The pathological biopsy was used as the gold standard. The diagnostic efficacy of ultrasound combined with mammography examination was significantly better than the other two single examinations (P<0.050). In conclusion, Doppler ultrasound parameters combined with MMP-11 has a high diagnostic accordance rate in the diagnosis of breast cancer. At the same time, different diagnostic methods combined with the clinical manifestations of patients can improve the diagnostic accuracy, which is worthy of providing reference and advice for future clinical practice.
探讨多普勒超声参数联合基质金属蛋白酶-11（MMP-11）在早期乳腺癌及乳腺良性疾病中的诊断价值。选取2015年3月至2018年8月在聊城市第三人民医院接受彩色多普勒超声检查的72例患者作为研究对象，并采集60例接受体检的健康受试者的血液。评估乳腺癌患者血清中MMP-11的表达水平，并评估彩色多普勒超声联合MMP-11对乳腺癌的诊断价值。记录彩色多普勒超声的诊断结果及乳腺癌患者的影像学特征。比较活检与超声检查结果。乳腺癌患者血清中MMP-11的表达水平显著高于健康受试者（P<0.05）。MMP-11的曲线下面积（AUC）为0.735，灵敏度为66.67%，特异度为86.11%。72例患者中，血清MMP-11检查诊断为乳腺癌的有41例，超声检查诊断为乳腺癌的有38例，联合诊断诊断为乳腺癌的有33例，病理活检诊断为乳腺癌的有30例。以病理活检作为金标准。超声联合乳腺钼靶检查的诊断效能显著优于其他两种单一检查（P<0.050）。综上所述，多普勒超声参数联合MMP-11在乳腺癌诊断中具有较高的诊断符合率。同时，不同诊断方法结合患者临床表现可提高诊断准确性，值得为今后的临床实践提供参考和建议。
