• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用生物信息学分析挖掘GINS2基因在人类乳腺癌中的预后意义。

Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis.

作者信息

Yu Shibo, Zhu Lizhe, Xie Peiling, Jiang Siyuan, Wang Ke, Liu Yang, He Jianjun, Ren Yu

机构信息

Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

出版信息

Oncol Lett. 2020 Aug;20(2):1300-1310. doi: 10.3892/ol.2020.11651. Epub 2020 May 20.

DOI:10.3892/ol.2020.11651
PMID:32724372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7377083/
Abstract

A number of studies have demonstrated the crucial functions of GINS2 within the GINS complex in various types of cancer. However, the molecular mechanisms and prognostic value of GINS2 in breast cancer remain unknown. The present study used; BC-GenExMiner, COSMIC, UCSC Xena, The Human Protein Atlas, GEPIA, cBioPortal, GeneMANIA, TIMER and Oncomine, in order to investigate gene expression, co-expression, clinical parameters and mutations in GINS2 in patients with breast cancer. Furthermore, the present study assessed the prognostic value of GINS2 in patients with breast cancer via the Kaplan-Meier plotter database. The results of the present study demonstrated that the mRNA levels of GINS2 were significantly higher in breast cancer tissue compared with normal tissue. In addition, high mRNA expression levels of GINS2 were associated with high Scarff-Bloom-Richardson status grades, a basal-like status and age (≤51 years); however, it was not associated with lymph node metastasis. The survival analysis revealed that increased GINS2 mRNA levels were associated with a worse prognosis for relapse-free survival in all patients with breast cancer, particularly in those with estrogen receptor-positive and progesterone receptor-positive subtypes. In addition, a positive association between the GINS2, CENPM and MCM4 genes was confirmed. The results of the present study suggest that GINS2 could be used as a potential prognostic biomarker for breast cancer. Nevertheless, further studies are necessary to confirm the effects of GINS2 on the pathogenesis and development of patients with breast cancer.

摘要

多项研究已证明GINS2在GINS复合物中在各类癌症中发挥着关键作用。然而，GINS2在乳腺癌中的分子机制和预后价值仍不清楚。本研究使用了BC-GenExMiner、COSMIC、UCSC Xena、人类蛋白质图谱、GEPIA、cBioPortal、GeneMANIA、TIMER和Oncomine，以研究乳腺癌患者中GINS2的基因表达、共表达、临床参数和突变情况。此外，本研究通过Kaplan-Meier plotter数据库评估了GINS2在乳腺癌患者中的预后价值。本研究结果表明，与正常组织相比，乳腺癌组织中GINS2的mRNA水平显著更高。此外，GINS2的高mRNA表达水平与高斯卡夫-布鲁姆-理查森分级、基底样状态和年龄（≤51岁）相关；然而，它与淋巴结转移无关。生存分析显示，GINS2 mRNA水平升高与所有乳腺癌患者无复发生存的较差预后相关，尤其是雌激素受体阳性和孕激素受体阳性亚型的患者。此外，还证实了GINS2、CENPM和MCM4基因之间存在正相关。本研究结果表明，GINS2可作为乳腺癌潜在的预后生物标志物。然而，需要进一步研究以证实GINS2对乳腺癌患者发病机制和发展的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/fdb36532c496/ol-20-02-1300-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/9560a751190c/ol-20-02-1300-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/630ab9239676/ol-20-02-1300-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/6067e73027b3/ol-20-02-1300-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/5e98721c630f/ol-20-02-1300-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/8a85adb7a317/ol-20-02-1300-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/ef539fb67e25/ol-20-02-1300-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/fdb36532c496/ol-20-02-1300-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/9560a751190c/ol-20-02-1300-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/630ab9239676/ol-20-02-1300-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/6067e73027b3/ol-20-02-1300-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/5e98721c630f/ol-20-02-1300-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/8a85adb7a317/ol-20-02-1300-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/ef539fb67e25/ol-20-02-1300-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4889/7377083/fdb36532c496/ol-20-02-1300-g07.jpg

相似文献

1
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis.利用生物信息学分析挖掘GINS2基因在人类乳腺癌中的预后意义。
Oncol Lett. 2020 Aug;20(2):1300-1310. doi: 10.3892/ol.2020.11651. Epub 2020 May 20.
2
High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients.高GINS2转录水平预示着乳腺癌患者预后不良，且通过乳腺癌干细胞与高组织学分级和内分泌治疗耐药相关。
Breast Cancer Res Treat. 2014 Nov;148(2):423-36. doi: 10.1007/s10549-014-3172-7. Epub 2014 Oct 28.
3
Bioinformatics analysis revealing prognostic significance of gene in breast cancer.生物信息学分析揭示基因在乳腺癌中的预后意义。
Biosci Rep. 2019 Apr 9;39(4). doi: 10.1042/BSR20182062. Print 2019 Apr 30.
4
Expression and prognosis analysis of GINS subunits in human breast cancer.GINS 亚基在人乳腺癌中的表达与预后分析。
Medicine (Baltimore). 2021 Mar 19;100(11):e24827. doi: 10.1097/MD.0000000000024827.
5
Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer.生物信息学分析 COL10A1 在乳腺癌中的预后意义。
Biosci Rep. 2020 Feb 28;40(2). doi: 10.1042/BSR20193286.
6
Bioinformatics analysis of prognostic value of PITX1 gene in breast cancer.生物信息学分析 PITX1 基因在乳腺癌中的预后价值。
Biosci Rep. 2020 Sep 30;40(9). doi: 10.1042/BSR20202537.
7
Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer.FBXO家族表达与预后相关性的系统分析揭示了FBXO1在人类乳腺癌中的意义。
Cancer Cell Int. 2021 Feb 23;21(1):130. doi: 10.1186/s12935-021-01833-y.
8
Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis.利用综合生物信息学分析鉴定乳腺癌中 BIRC5 的预后意义。
Biosci Rep. 2020 Feb 28;40(2). doi: 10.1042/BSR20193678.
9
Vitamin D receptor () mRNA overexpression is associated with poor prognosis in breast carcinoma.维生素D受体（）信使核糖核酸过表达与乳腺癌的不良预后相关。
Ann Surg Treat Res. 2022 Oct;103(4):183-194. doi: 10.4174/astr.2022.103.4.183. Epub 2022 Oct 7.
10
Prognostic Significance of Prostaglandin-Endoperoxide Synthase-2 Expressions in Human Breast Carcinoma: A Multiomic Approach.前列腺素内过氧化物合酶-2表达在人类乳腺癌中的预后意义：一种多组学方法
Cancer Inform. 2020 Nov 6;19:1176935120969696. doi: 10.1177/1176935120969696. eCollection 2020.

引用本文的文献

1
Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes.乳腺癌预后的分子生物标志物：氨基酸代谢基因的作用
J Physiol Biochem. 2025 Jun 10. doi: 10.1007/s13105-025-01088-5.
2
E2F1-mediated GINS2 transcriptional activation promotes tumor progression through PI3K/AKT/mTOR pathway in hepatocellular carcinoma.E2F1介导的GINS2转录激活通过PI3K/AKT/mTOR途径促进肝细胞癌的肿瘤进展。
Am J Cancer Res. 2022 Apr 15;12(4):1707-1726. eCollection 2022.

本文引用的文献

1
Integration and Analysis of CPTAC Proteomics Data in the Context of Cancer Genomics in the cBioPortal.CPTAC 蛋白质组学数据在 cBioPortal 癌症基因组学背景下的整合与分析。
Mol Cell Proteomics. 2019 Sep;18(9):1893-1898. doi: 10.1074/mcp.TIR119.001673. Epub 2019 Jul 15.
2
Up-regulated and interrelated expressions of GINS subunits predict poor prognosis in hepatocellular carcinoma.GINS 亚基的上调和相互关联的表达可预测肝细胞癌的不良预后。
Biosci Rep. 2018 Dec 7;38(6). doi: 10.1042/BSR20181178. Print 2018 Dec 21.
3
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
4
Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets.使用独立数据集的表达数据验证 miRNA 在肝细胞癌中的预后能力。
Sci Rep. 2018 Jun 15;8(1):9227. doi: 10.1038/s41598-018-27521-y.
5
The new TNM-based staging of breast cancer.乳腺癌的新 TNM 分期。
Virchows Arch. 2018 May;472(5):697-703. doi: 10.1007/s00428-018-2301-9. Epub 2018 Jan 27.
6
TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells.TIMER：用于肿瘤浸润免疫细胞综合分析的网络服务器。
Cancer Res. 2017 Nov 1;77(21):e108-e110. doi: 10.1158/0008-5472.CAN-17-0307.
7
Prognostic and predictive biomarkers in breast cancer: Past, present and future.乳腺癌的预后和预测生物标志物：过去、现在和未来。
Semin Cancer Biol. 2018 Oct;52(Pt 1):56-73. doi: 10.1016/j.semcancer.2017.08.010. Epub 2017 Sep 4.
8
A pathology atlas of the human cancer transcriptome.人类癌症转录组病理学图谱。
Science. 2017 Aug 18;357(6352). doi: 10.1126/science.aan2507.
9
A subcellular map of the human proteome.人类蛋白质组的亚细胞图谱。
Science. 2017 May 26;356(6340). doi: 10.1126/science.aal3321. Epub 2017 May 11.
10
Specific amplifications and copy number decreases during human neural stem cells differentiation towards astrocytes, neurons and oligodendrocytes.人类神经干细胞向星形胶质细胞、神经元和少突胶质细胞分化过程中的特定扩增和拷贝数减少。
Oncotarget. 2017 Apr 18;8(16):25872-25884. doi: 10.18632/oncotarget.15980.