Wu Lina, Zou Hongyan, Wang Hongbin, Zhang Sihang, Liu Shuang, Jiang Ying, Chen Jing, Li Yingbo, Shao Mengping, Zhang Ruixin, Li Xiaona, Dong Jing, Yang Lili, Wang Kai, Zhu Xinyuan, Sun Xilin
NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, China.
TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jan;13(1):e1660. doi: 10.1002/wnan.1660. Epub 2020 Jul 29.
Molecular imaging has received increased attention worldwide, including in China, because it offers noninvasive characterization of widely diverse clinically significant pathologies. To achieve these goals, nanomedicine has evolved into a broad interdisciplinary field with flexible designs to accommodate and concentrate imaging and therapeutic payloads into pathological cells through selective binding to disease specific cell membrane biomarkers. This concept of personalized medicine reflects the vision of "magic bullets" proposed by German biochemist Paul Ehrlich over 100 years ago. As happening worldwide, Chinese scientists are contributing to this tsunami of science and technologies through impactful national programs and international research collaborations. This review provides a comprehensive update of Chinese innovations to address intractable unmet medical need in China and worldwide in the optical sciences. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging.
分子成像在全球范围内受到越来越多的关注，包括在中国，因为它能够对多种具有临床意义的病理情况进行无创表征。为实现这些目标，纳米医学已发展成为一个广泛的跨学科领域，其设计灵活，可通过与疾病特异性细胞膜生物标志物的选择性结合，将成像和治疗载荷容纳并集中到病理细胞中。这种个性化医疗的概念反映了德国生物化学家保罗·埃尔利希在100多年前提出的“神奇子弹”愿景。正如在全球范围内所发生的那样，中国科学家正通过有影响力的国家项目和国际研究合作，为这场科技浪潮做出贡献。本综述全面更新了中国在光学科学领域为解决中国乃至全球棘手的未满足医疗需求所做出的创新。本文分类如下：诊断工具>体内纳米诊断与成像。
