Mine Keiichiro, Yoshikai Yasunobu, Takahashi Hirokazu, Mori Hitoe, Anzai Keizo, Nagafuchi Seiho
Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan.
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Microorganisms. 2020 Jul 27;8(8):1133. doi: 10.3390/microorganisms8081133.
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.
肠道病毒，尤其是柯萨奇B病毒，是1型糖尿病潜在的环境致病因素之一。宿主遗传因素会影响病毒诱导的糖尿病（VID）的发展。在分析靶基因在VID中的作用时，还应考虑宿主背景，即宿主是否易患自身免疫性疾病。在这篇综述中，我们根据对人类和VID动物模型的研究描述了宿主的遗传易感性。了解宿主遗传因素不仅有助于揭示VID的发病机制，也有助于采取措施预防VID。
