Department of Anesthesiology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Department of Ultrasound, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
J Invest Surg. 2021 Dec;34(12):1297-1303. doi: 10.1080/08941939.2020.1797949. Epub 2020 Jul 30.
Perioperative neurocognitive disorders (PND) resulting from cardiac surgery is a complication with high morbidity and mortality. However, the pathogenesis is unknown.
For the sake of investigating the risk factors and mechanism of PND, we collected the characteristics and neurological scores of patients undergoing cardiac surgery in the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University and Affiliated Hospital of Southwest Medical University from Jan 1, 2016 to Dec 11, 2018.
We found that age and left atrial thrombus are independent risk factors for PND after cardiac surgery. Furthermore, the serum of 29 patients was collected on the 7th day after cardiac surgery for detecting the expression of lncRNA-MYL2-2 and miR-124-3p. Increased lncRNA-MYL2-2 and decreased miR-124-3p in serum were associated with the decline of patients' cognition.
LncRNA-MYL2-2 and miRNA-124-3p may jointly participate in the occurrence and development of PND after cardiac surgery. These important findings are advantaged to further understand the pathogenesis of PND and prevent it, provide new biomarkers for the diagnosis and monitoring of PND.
心脏手术后出现的围手术期神经认知障碍（PND）是一种发病率和死亡率都很高的并发症。然而，其发病机制尚不清楚。
为了研究 PND 的危险因素和发病机制，我们收集了西南医科大学附属医院及西南医科大学附属医院 2016 年 1 月 1 日至 2018 年 12 月 11 日接受心脏手术的患者的特征和神经评分。
我们发现，年龄和左心房血栓是心脏手术后 PND 的独立危险因素。此外，我们在心脏手术后第 7 天收集了 29 名患者的血清，用于检测长链非编码 RNA-MYL2-2 和 miR-124-3p 的表达。血清中 lncRNA-MYL2-2 表达增加和 miR-124-3p 表达降低与患者认知功能下降有关。
lncRNA-MYL2-2 和 miRNA-124-3p 可能共同参与心脏手术后 PND 的发生和发展。这些重要发现有助于进一步了解 PND 的发病机制并加以预防，为 PND 的诊断和监测提供新的生物标志物。
