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严重精神疾病患者或家庭医生中使用抗精神病药物患者的心血管风险筛查。

Cardiovascular risk screening of patients with serious mental illness or use of antipsychotics in family practice.

机构信息

Department of Primary and Community Care (117-ELG), Radboud University Medical Centre, Radboud Institute for Health Sciences, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.

出版信息

BMC Fam Pract. 2020 Jul 29;21(1):153. doi: 10.1186/s12875-020-01225-7.

Abstract

BACKGROUND

Patients with serious mental illness (SMI) and patients on antipsychotics (AP) have an elevated risk for cardiovascular diseases. In the Netherlands, the mental healthcare for these patients is increasingly taken care of by family practitioners (FP) as a result of a shift from secondary to primary care. Therefore, it is essential to increase our knowledge regarding the characteristics of this patient group and the (somatic) care provided by their FPs. The aim was to examine the rate of cardiovascular risk screening in patients with SMI or the use of AP in family practice.

METHODS

We performed a retrospective cohort study of 151.238 patients listed in 24 family practices in the Netherlands. From electronic medical records we extracted data concerning diagnoses, measurement values of CVR factors, medication and frequency of visits over a 2 year period. Primary outcome was the rate of patients who were screened for CVR factors. We compared three groups: patients with SMI/AP without diabetes or CVD (SMI/AP-only), patients with SMI/AP and diabetes mellitus (SMI/AP + DM), patients with SMI/AP and a history of cardiovascular disease (SMI/AP + CVD). We explored factors associated with adequate screening using multilevel logistic regression.

RESULTS

We identified 1705 patients with SMI/AP, 834 with a SMI diagnosis, 1150 using AP. The screening rate for CVR in the SMI/AP-only group (n = 1383) was adequate in 8.5%. Screening was higher in the SMI/AP - +DM (n = 206, 68.4% adequate, OR 24.6 (95%CI, 17.3-35.1) and SMI/AP + CVD (n = 116, 26.7% adequate, OR 4.2 (95%CI, 2.7-6.6). A high frequency of visits, age, the use of AP and a diagnosis of COPD were associated with a higher screening rate. In addition we also examined differences between patients with SMI and patients using AP without SMI.

CONCLUSION

CVR screening in patients with SMI/AP is performed poorly in Dutch family practices. Acceptable screening rates were found only among SMI/AP patients with diabetes mellitus as comorbidity. The finding of a large group of AP users without a SMI diagnosis may indicate that FPs often prescribe AP off-label, lack information about the diagnosis, or use the wrong code.

摘要

背景

患有严重精神疾病(SMI)和使用抗精神病药物(AP)的患者心血管疾病风险较高。在荷兰,由于从二级医疗保健向初级医疗保健转变,这些患者的精神卫生保健越来越由家庭医生(FP)负责。因此,增加我们对该患者群体特征以及其家庭医生提供的(躯体)护理的了解至关重要。目的是检查 SMI 患者或在家庭实践中使用 AP 的心血管风险筛查率。

方法

我们对荷兰 24 个家庭诊所的 151238 名患者进行了回顾性队列研究。我们从电子病历中提取了 2 年内与诊断、心血管风险因素测量值、药物使用和就诊频率相关的数据。主要结果是筛查心血管风险因素的患者比例。我们比较了三组:无糖尿病或心血管疾病(SMI/AP-仅)的 SMI/AP 患者、患有 SMI/AP 和糖尿病(SMI/AP+DM)的患者、患有 SMI/AP 和心血管疾病史(SMI/AP+CVD)的患者。我们使用多级逻辑回归探索了与适当筛查相关的因素。

结果

我们确定了 1705 名患有 SMI/AP 的患者,其中 834 名患有 SMI 诊断,1150 名使用 AP。在 SMI/AP-仅组(n=1383)中,心血管风险筛查的适当率为 8.5%。在 SMI/AP-+DM 组(n=206)中,筛查率较高(68.4%适当,OR 24.6(95%CI,17.3-35.1)和 SMI/AP+CVD 组(n=116)中,适当筛查率为 26.7%(OR 4.2(95%CI,2.7-6.6)。就诊频率高、年龄较大、使用 AP 和 COPD 诊断与较高的筛查率相关。此外,我们还比较了患有 SMI 的患者和未患有 SMI 的使用 AP 的患者之间的差异。

结论

荷兰家庭诊所对 SMI/AP 患者的心血管风险筛查效果不佳。只有患有 SMI/AP 合并糖尿病的患者才能发现可接受的筛查率。发现一大群未患有 SMI 诊断的 AP 使用者可能表明,家庭医生经常超说明书使用 AP,缺乏对诊断的了解,或使用错误的代码。

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