Continuous monitoring of gas exchange and oxygen use with dual oximetry.

The utility of integrated pulse and pulmonary artery oximetry, known as dual oximetry, was evaluated by monitoring 10 critically ill surgical patients for a total of 208 patient hours. The ventilation-perfusion index (VQI), an estimate of venous admixture, and the oxygen extraction index (O2EI), an estimate of tissue oxygen utilization coefficient, previously described, were calculated on-line from arterial and mixed venous oxyhemoglobin saturations using a computer. Effective monitoring was accomplished 85% of the total time. The dual oximetry device was nonfunctional owing to equipment failure only 15% of the time, even though no undue attention was given to instructing the staff on operation of the oximeters. Accuracy of VQI and O2EI was reconfirmed by this study. Drift in the saturations, VQI, and O2EI during the 6-h period between calibrations was negligible. The 95% range of random variability was +/- 2% for SaO2, +/- 3% for SvO2, +/- 5% for VQI, and +/- 0.04 for O2EI. Thirty-six episodes of arterial blood desaturation below 90% were detected by continuous oximetry. In contrast, 74 routine arterial blood samples revealed only four such episodes. Dual oximetry appears to be a technically reliable and accurate method of monitoring pulmonary gas exchange and tissue oxygen utilization. The equipment provided stable readings for at least six hours without recalibration. Random variability is sufficiently small to allow early detection of alterations in pulmonary and circulatory function without blood sampling.