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Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation.

作者信息

Liu Shan-Shan, Qi Jie, Teng Zu-Dong, Tian Fu-Tao, Lv Xiao-Xi, Li Ke, Song Ya-Jie, Xie Wei-Dong, Hu Zhuo-Wei, Li Xia

机构信息

Department of Pharmacy, Marine College, Shandong University, Weihai, 264209, China.

Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.

出版信息

Signal Transduct Target Ther. 2020 Jul 29;5(1):133. doi: 10.1038/s41392-020-00255-y.

DOI:10.1038/s41392-020-00255-y
PMID:32728028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7391765/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/7391765/dd4c299072c8/41392_2020_255_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/7391765/dd4c299072c8/41392_2020_255_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c0/7391765/dd4c299072c8/41392_2020_255_Fig1_HTML.jpg

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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development.
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