Dentistry Post-Graduation Program of Federal, University of Pará, Augusto Correa Street, 01, Belém, PA, 66075-110, Brazil.
Ophir Loyola Hospital, Governador Magalhães Barata Avenue, 992, Belém, PA, 66063-240, Brazil.
Sci Rep. 2020 Jul 29;10(1):12690. doi: 10.1038/s41598-020-68932-0.
We evaluated bioactive glass graft (S53P4) in patients undergoing Le Fort I osteotomy, with non-grafted patients as controls. Computed tomography facial scans of the 25 patients submitted for Le Fort I were divided into two groups: Group 1-S53P4 group and Group 2-without grafting. CT scans were analyzed in the immediate postoperative period (T1) and 6 months later (T2), for linear bone gap measurements, tomographic radiodensity and behavior of the maxillary sinus. A Kruskal-Wallis test on bone gap data adopted α significance levels (p ≤ 0.05). The Friedman test (p ≤ 0.05) was used to evaluate sinus reaction cores. For gap measurements, we observed a decrease in median data between T1 and T2 in both groups, with statistical significances observed between groups in T0; G1 presented statistical difference in its two studied times (p ≤ 0.0001). For bone density, the studied data behaved inversely. G1's bone density decreased from T1 to T2, whereas in G2 there was an increase from T1 to T2. S53P4 did not elicit increased reactions and/or sinus infections in the G1 group (p ≥ 1.00). S53P4 did not impact on Le Fort I osteotomies as a coadjuvant and a favorable factor in bone formation, and appeared innocuous in the maxillary sinus.
我们评估了接受 Le Fort I 截骨术的患者中生物活性玻璃移植物（S53P4）的效果，将未进行移植物移植的患者作为对照组。将 25 名接受 Le Fort I 手术的患者的面部 CT 扫描分为两组：S53P4 组（第 1 组）和未进行移植组（第 2 组）。对 CT 扫描进行了即刻术后（T1）和 6 个月后（T2）的线性骨间隙测量、断层放射密度和上颌窦的变化。采用 Kruskal-Wallis 检验对骨间隙数据进行了分析，采用α显著性水平（p≤0.05）。采用 Friedman 检验（p≤0.05）对窦反应核进行了评估。对于间隙测量，我们观察到两组在 T1 和 T2 之间的中位数数据都有所减少，T0 时两组之间有统计学差异；G1 在两个研究时间点都有统计学差异（p≤0.0001）。对于骨密度，研究数据则呈现出相反的趋势。G1 的骨密度从 T1 到 T2 降低，而 G2 则从 T1 到 T2 增加。S53P4 没有在 G1 组引起更多的反应和/或窦感染（p≥1.00）。S53P4 作为 Le Fort I 截骨术的辅助手段并没有影响骨形成，而且在上颌窦中似乎没有危害。
