COVID-19 中中性粒细胞诱导的氧化应激导致的组织损伤。
Tissue damage from neutrophil-induced oxidative stress in COVID-19.
机构信息
CNRS, INSERM UMRS 1124, Faculté des sciences fondamentales et biomédicales, Université de Paris, Paris, France.
Centre de Recherche Saint-Antoine, INSERM UMRS 938, Sorbonne Université, Paris, France.
出版信息
Nat Rev Immunol. 2020 Sep;20(9):515-516. doi: 10.1038/s41577-020-0407-1.
The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
在 COVID-19 重症患者中观察到的高中性粒细胞与淋巴细胞比值与活性氧（ROS）的过度水平有关，ROS 会引发一系列生物学事件，从而导致病理性宿主反应。ROS 会引起组织损伤、血栓形成和红细胞功能障碍，从而导致 COVID-19 疾病的严重程度。我们认为，自由基清除剂可能对最脆弱的患者有益。
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