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Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.

作者信息

Omarjee Loukman, Janin Anne, Perrot Frédérique, Laviolle Bruno, Meilhac Olivier, Mahe Guillaume

机构信息

Inserm, NuMeCan Institute (UMR INSERM 1241), Rennes F-35033, France; Univ Rennes, CHU Rennes, INSERM, CIC1414, Clinical Immunology and Vascular Medicine, Rennes F-35033, France.

Inserm, (U942), Paris Diderot University, Sorbonne Paris Cité, Paris F-75018, France.

出版信息

Clin Immunol. 2020 Jul;216:108464. doi: 10.1016/j.clim.2020.108464. Epub 2020 May 13.

DOI:10.1016/j.clim.2020.108464
PMID:32405269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7217787/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd9/7217787/6da4b889df38/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd9/7217787/6da4b889df38/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd9/7217787/6da4b889df38/gr1_lrg.jpg

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Front Immunol. 2020 May 1;11:827. doi: 10.3389/fimmu.2020.00827. eCollection 2020.
2
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.抗炎药物在治疗重症新型冠状病毒病 2019（COVID-19）患者中的应用：来自中国临床免疫学家的观点。
Clin Immunol. 2020 May;214:108393. doi: 10.1016/j.clim.2020.108393. Epub 2020 Mar 25.
3
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib.
新型冠状病毒肺炎相关肝损伤：风险群体机制与管理的最新综述
Liver Res. 2023 Jul 13;7(3):207-215. doi: 10.1016/j.livres.2023.07.001. eCollection 2023 Sep.
4
Unveiling the potential pleiotropic effects of metformin in treating COVID-19: a comprehensive review.揭示二甲双胍治疗新冠肺炎的潜在多效性：一项综述
Front Mol Biosci. 2023 Oct 10;10:1260633. doi: 10.3389/fmolb.2023.1260633. eCollection 2023.
5
COVID-19: Variants, Immunity, and Therapeutics for Non-Hospitalized Patients.COVID-19：非住院患者的变体、免疫与治疗方法
Biomedicines. 2023 Jul 21;11(7):2055. doi: 10.3390/biomedicines11072055.
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Targeting Immune Senescence in Atherosclerosis.靶向动脉粥样硬化中的免疫衰老。
Int J Mol Sci. 2022 Oct 27;23(21):13059. doi: 10.3390/ijms232113059.
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J Clin Invest. 2022 Dec 15;132(24):e160766. doi: 10.1172/JCI160766.
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