Piekarska Anna, Tomasiewicz Krzysztof, Halota Waldemar, Jaroszewicz Jerzy, Krygier Rafał, Małkowski Piotr, Pawłowska Małgorzata, Simon Krzysztof, Tronina Olga, Zarębska-Michaluk Dorota, Flisiak Robert
Department of Infectious Diseases and Hepatology, Medical University of Łódz, Łódź, Poland.
Department of Infectious Diseases and Hepatology, Medical University of Lublin, Lublin, Poland.
Clin Exp Hepatol. 2020 Jun;6(2):74-76. doi: 10.5114/ceh.2020.94969. Epub 2020 Apr 30.
The purpose of the study was to select the optimal target population for a possible national hepatitis C virus (HCV) screening program in Poland, based on the most recent available data.
The analysis included 723,654 participants from different populations screened for anti-HCV. Testing was performed in the whole blood using rapid anti-HCV kits. Presence of HCV RNA was additionally demonstrated in some anti-HCV positive patients with the real-time polymerase chain reaction method.
Altogether 3,548 anti-HCV positive individuals were identified, so the prevalence rate in the whole studied population was 0.5%. The highest percentage (1.2%) was shown by diagnostic laboratories, which offered rapid testing for patients visiting their offices during the HCV awareness campaign. Relatively high anti-HCV prevalence of 0.6-0.7% was noted in hospitals and in private medical centers, as well as during music concerts. Surprisingly, the lowest prevalence (0.2%) was observed in general practitioners' offices. Among 502 anti-HCV positive individuals tested additionally for HCV RNA, viremic presence was demonstrated in 40%.
Anti-HCV testing in Poland should be carried out using rapid anti-HCV kits at the patients' admission to the hospitals and should also be offered to patients during their visits for any purpose in diagnostic laboratories or private medical centers.
本研究的目的是根据最新可得数据，为波兰可能开展的全国丙型肝炎病毒（HCV）筛查项目选择最佳目标人群。
分析纳入了723,654名来自不同人群的抗-HCV筛查参与者。使用快速抗-HCV试剂盒对全血进行检测。部分抗-HCV阳性患者还采用实时聚合酶链反应法检测HCV RNA的存在情况。
共识别出3548名抗-HCV阳性个体，因此整个研究人群中的患病率为0.5%。诊断实验室的患病率最高（1.2%），这些实验室在HCV宣传活动期间为前来就诊的患者提供快速检测。在医院、私人医疗中心以及音乐会期间，抗-HCV患病率相对较高，为0.6%-0.7%。令人惊讶的是，在全科医生办公室观察到的患病率最低（0.2%）。在502名额外检测HCV RNA的抗-HCV阳性个体中，40%检测到病毒血症。
在波兰，应在患者入院时使用快速抗-HCV试剂盒进行抗-HCV检测，并且在诊断实验室或私人医疗中心，也应为因任何目的前来就诊的患者提供检测。
