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中欧距离消除丙型肝炎病毒还有多远?

How close are we to hepatitis C virus elimination in Central Europe?

作者信息

Flisiak Robert, Frankova Sona, Grgurevic Ivica, Hunyady Bela, Jarcuska Peter, Kupčinskas Limas, Makara Michael, Simonova Marieta, Sperl Jan, Tolmane Ieva, Vince Adriana, Zarębska-Michaluk Dorota

机构信息

Department of Infectious Diseases and Hepatology, Medical University of Białystok, Poland.

Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

出版信息

Clin Exp Hepatol. 2020 Feb;6(1):1-8. doi: 10.5114/ceh.2020.93049. Epub 2020 Feb 17.

Abstract

AIM OF THE STUDY

To collect and analyse data obtained from HCV opinion leaders/experts from central European countries, on factors which can affect the WHO target of HCV elimination by 2030.

MATERIAL AND METHODS

Data were collected from opinion leaders/experts involved in management of HCV infections in Central European countries which participated in 9 Conference of the Central European Hepatologic Collaboration (Warsaw, 10-11 October 2019). A dedicated questionnaire collected current information related to HCV elimination in Bulgaria, Croatia, the Czech Republic, Hungary, Latvia, Lithuania, Poland and Slovakia.

RESULTS

The HCV prevalence rate in particular countries varied from 0.2% to 1.7%. In most central European countries all the HCV infected population is eligible for reimbursement of treatment. However, in some countries there are still some limitations related to the stage of the disease and people who inject drugs. All countries have access to at least one pangenotypic regimen. The most common barrier to HCV elimination in all countries is insufficient political will to establish priority for HCV. None of the reporting countries has established a national screening programme.

CONCLUSIONS

Access to therapy for HCV is similar and the majority of patients in Central Europe can be treated according to the current guidelines. Unfortunately there are still some limitations and a lack of political will to implement national screening programmes. According to collected data HCV elimination will not be possible in the region by 2030.

摘要

研究目的

收集并分析从中欧国家丙型肝炎意见领袖/专家处获得的数据,这些数据涉及可能影响世界卫生组织2030年消除丙型肝炎目标的因素。

材料与方法

数据收集自参与2019年10月10 - 11日在华沙举行的第9届中欧肝病协作会议的中欧国家丙型肝炎感染管理方面的意见领袖/专家。一份专门的调查问卷收集了保加利亚、克罗地亚、捷克共和国、匈牙利、拉脱维亚、立陶宛、波兰和斯洛伐克与丙型肝炎消除相关的当前信息。

结果

特定国家的丙型肝炎患病率在0.2%至1.7%之间。在大多数中欧国家,所有丙型肝炎感染人群都有资格获得治疗费用报销。然而,在一些国家,在疾病阶段和注射吸毒者方面仍存在一些限制。所有国家都至少能获得一种泛基因型治疗方案。所有国家消除丙型肝炎最常见的障碍是缺乏将丙型肝炎列为优先事项的政治意愿。没有一个报告国家建立了全国性筛查计划。

结论

丙型肝炎治疗的可及性相似,中欧的大多数患者可以按照现行指南进行治疗。不幸的是,在实施全国性筛查计划方面仍存在一些限制且缺乏政治意愿。根据收集的数据,该地区到2030年不可能消除丙型肝炎。

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