Elgammal Nahla, Zaher Tarik I, Elkomy Hoida, Abdelmoaty Ahmed Attia, Abdallah Mohamed, Emara Mohamed H
Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clin Exp Hepatol. 2020 Jun;6(2):150-157. doi: 10.5114/ceh.2020.95940. Epub 2020 Jun 10.
Liver cirrhosis is an irreversible destructive liver disease that is associated with a wide range of complications. Among the recognized comorbidities of liver cirrhosis are sleep-disordered breathing (SDB), which is being more and more often described among cirrhotics. This study aimed to detect the prevalence of SDB among Egyptian post-viral cirrhotic adults.
This study enrolled 48 post-viral cirrhotic patients and 16 apparently healthy control subjects. All patients and controls were evaluated by thorough history taking, full clinical examination, laboratory investigations, the Epworth Sleepiness Scale questionnaire, the Berlin Questionnaire and polysomnography.
Patients and controls were comparable as regards baseline demographics. Patients with liver cirrhosis had higher frequency of SDB compared to controls (56.2% vs. 12.5%, = 0.002). The most frequently encountered SBD patterns among cirrhotics were obstructive sleep apnea and apnea hypopnea index. Moreover, SDB was more severe among cirrhotics (25% were mild, 16.6% were moderate and 14.6% were severe obstructive sleep apnea - OSA) compared to the healthy controls (all were mild).
It seems that post-viral cirrhotic patients had a wide range of SDB with variable degrees of severity compared to the healthy controls.
肝硬化是一种不可逆的肝脏破坏性疾病，伴有多种并发症。肝硬化公认的合并症包括睡眠呼吸障碍（SDB），在肝硬化患者中越来越多地被描述。本研究旨在检测埃及病毒感染后肝硬化成年患者中SDB的患病率。
本研究纳入了48例病毒感染后肝硬化患者和16例明显健康的对照者。所有患者和对照者均通过详细的病史采集、全面的临床检查、实验室检查、爱泼华嗜睡量表问卷、柏林问卷和多导睡眠图进行评估。
患者和对照者在基线人口统计学方面具有可比性。肝硬化患者的SDB发生率高于对照者（56.2%对12.5%，P = 0.002）。肝硬化患者中最常见的SBD模式是阻塞性睡眠呼吸暂停和呼吸暂停低通气指数。此外，与健康对照者（均为轻度）相比，肝硬化患者的SDB更严重（25%为轻度，16.6%为中度，14.6%为重度阻塞性睡眠呼吸暂停 - OSA）。
与健康对照者相比，病毒感染后肝硬化患者似乎存在广泛的SDB，且严重程度各不相同。
