J Am Podiatr Med Assoc. 2020 May 1;110(3). doi: 10.7547/18-102.
Onychomycosis is the most common infectious nail disorder. Direct mycologic examination is still the cornerstone of diagnosis; however, it may take several weeks to obtain a result. Recently some dermoscopic patterns that can be useful in the diagnosis of onychomycosis were described. However, published data on dermoscopic features of onychomycosis are still limited.
We performed a prospective dermoscopic study of patients with positive fungal culture between April and December 2016. Patients with a final diagnosis of psoriasis or lichen planus were excluded from the study. Dermoscopy (polarized and nonpolarized) was performed.
Thirty-seven patients were enrolled, 24 women and 13 men (median ± SD age, 48.6 ± 16.1 years). Nail samples were culture positive for Trichophyton rubrum (89.2%), Trichophyton interdigitale (8.1%), and Candida albicans (2.7%). Distal and lateral subungual onychomycosis was the most frequent clinical subtype (59.5%). The most frequent dermoscopic features were subungual keratosis (73.0%), distal subungual longitudinal striae (70.3%), spikes of the proximal margin of an onycholytic area (59.5%), transverse superficial leukonychia (29.7%), and linear hemorrhage (13.5%). Brown chromonychia was most frequently seen with nonpolarized dermoscopy (66.6% versus 24%; P = .027).
Specific dermoscopic signs of onychomycosis are mostly related to the proximal invasion of the nail plate. Detection of these signs is simple and can, in some cases, help avoid mycologic testing.
甲真菌病是最常见的传染性甲病。直接真菌镜检仍然是诊断的基石;然而,可能需要数周才能得到结果。最近描述了一些在甲真菌病诊断中可能有用的皮肤镜模式。然而,关于甲真菌病的皮肤镜特征的已发表数据仍然有限。
我们对 2016 年 4 月至 12 月期间真菌培养阳性的患者进行了前瞻性皮肤镜研究。患有银屑病或扁平苔藓的患者被排除在研究之外。进行了皮肤镜(偏振和非偏振)检查。
共纳入 37 例患者,其中女性 24 例,男性 13 例(中位±标准差年龄,48.6±16.1 岁)。指甲样本培养出红色毛癣菌(89.2%)、须癣毛癣菌(8.1%)和白色念珠菌(2.7%)。远端和侧位甲下型甲真菌病是最常见的临床亚型(59.5%)。最常见的皮肤镜特征是甲下角化过度(73.0%)、远端甲下纵向条纹(70.3%)、甲分离区近端边缘的刺状突起(59.5%)、横形浅表白甲(29.7%)和线性出血(13.5%)。非偏振皮肤镜检查时,棕色甲变色最常见(66.6%与 24%;P=.027)。
甲真菌病的特定皮肤镜征象主要与甲板近端侵犯有关。这些征象的检测简单易行,在某些情况下可以帮助避免真菌检测。