铬补充剂对 2 型糖尿病患者血糖控制的影响：系统评价和随机对照试验的荟萃分析。
Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
机构信息
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Science, Tehran, Iran.
出版信息
Pharmacol Res. 2020 Nov;161:105098. doi: 10.1016/j.phrs.2020.105098. Epub 2020 Jul 28.
BACKGROUND
We aimed to investigate the effect of chromium supplementation on glycemic control indices in patients with type 2 diabetes (T2DM).
METHODS
Randomized controlled trials examining the effect of chromium supplementation on glycemic control indices and published before February 2020 were detected by searching online databases, including PubMed, Scopus, Embase, Web of sciences and The Cochrane Library, using a combination of suitable keywords. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the supplementation group and the control group at follow-up.
RESULTS
Twenty-eight studies reported fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C) and homeostatic model assessment for insulin resistance (HOMA-IR) as an outcome measure. Results revealed significant reduction in FPG (weighted mean difference (WMD): -19.00 mg/dl, 95% CI: -36.15, -1.85, P = 0.030; I: 99.8%, p < 0.001), insulin level (WMD: -12.35 pmol/l, 95% CI: -17.86, -6.83, P < 0.001), HbA1C (WMD: -0.71 %, 95% CI: -1.19, -0.23, P = 0.004) and HOMA-IR (WMD: -1.53, 95% CI: -2.35, -0.72, P < 0.001; I: 89.9%, p < 0.001) after chromium supplementation.
CONCLUSION
The results of the current meta-analysis study might support the use of chromium supplementation for the improvement of glycemic control indices in T2DM patients.
背景
本研究旨在探讨补充铬对 2 型糖尿病（T2DM）患者血糖控制指标的影响。
方法
通过检索在线数据库，包括 PubMed、Scopus、Embase、Web of sciences 和 The Cochrane Library，使用合适的关键词组合，查找截至 2020 年 2 月前关于铬补充对血糖控制指标影响的随机对照试验。采用均数差值（MD）和标准差（SD）来估计随访时补充组与对照组之间的结局指标差异。
结果
28 项研究报告了空腹血糖（FPG）、胰岛素、糖化血红蛋白（HbA1C）和稳态模型评估的胰岛素抵抗（HOMA-IR）作为结局指标。结果显示，FPG（MD：-19.00mg/dl，95%可信区间：-36.15，-1.85，P=0.030；I²：99.8%，p<0.001）、胰岛素水平（MD：-12.35pmol/L，95%可信区间：-17.86，-6.83，P<0.001）、HbA1C（MD：-0.71%，95%可信区间：-1.19，-0.23，P=0.004）和 HOMA-IR（MD：-1.53，95%可信区间：-2.35，-0.72，P<0.001；I²：89.9%，p<0.001）在补充铬后均显著降低。
结论
本荟萃分析结果可能支持在 T2DM 患者中使用铬补充来改善血糖控制指标。
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