Pham Thao N D, Spaulding Christina, Munshi Hidayatullah G
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
Cancers (Basel). 2020 Jul 28;12(8):2096. doi: 10.3390/cancers12082096.
A number of studies have clearly established the oncogenic role for MAPK-interacting protein kinases (MNK) in human malignancies. Modulation of MNK activity affects translation of mRNAs involved in cancer development, progression, and resistance to therapies. As a result, there are ongoing efforts to develop and evaluate MNK inhibitors for cancer treatment. However, it is important to recognize that MNK activity also plays an important role in regulating the innate and adaptive immune systems. A better understanding of the role of MNK kinases and MNK-mediated signals in regulating the immune system could help mitigate undesired side effects while maximizing therapeutic efficacy of MNK inhibitors. Here, we provide a systematic review on the function of MNK kinases and their substrates in immune cells.
多项研究已明确证实丝裂原活化蛋白激酶相互作用蛋白激酶（MNK）在人类恶性肿瘤中的致癌作用。MNK活性的调节会影响参与癌症发展、进展和治疗耐药性的mRNA的翻译。因此，人们正在不断努力开发和评估用于癌症治疗的MNK抑制剂。然而，必须认识到MNK活性在调节先天性和适应性免疫系统中也起着重要作用。更好地了解MNK激酶和MNK介导的信号在调节免疫系统中的作用，有助于在最大化MNK抑制剂治疗效果的同时减轻不良副作用。在此，我们对MNK激酶及其底物在免疫细胞中的功能进行了系统综述。
