Design Programme, Indian Institute of Technology, Kanpur, U.P. 208016, India; Microsystems Fabrication Laboratory, Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, U.P. 208016, India; Singapore University of Technology and Design, 487372 Singapore.
Department of Biological Sciences, St. John's University, New York, N.Y 11439, USA.
Enzyme Microb Technol. 2020 Sep;139:109558. doi: 10.1016/j.enzmictec.2020.109558. Epub 2020 Apr 21.
Recent trends in biosensing research have motivated scientists and research professionals to investigate the development of miniaturized bioanalytical devices to make them portable, label-free and smaller in size. The performance of the cantilever-based devices which is one of the very important domains of sensitive field level detection has improved significantly with the development of new micro/nanofabrication technologies and surface functionalization techniques. The cantilevers have scaled down to Nano from micro-level and have become exceptionally sensitive and also have some anomalous associated properties due to the scale. In this review we have discussed about fundamental principles of cantilever operation, detection methods, and previous, present and future approaches of study through cantilever-based sensing platform. Other than that, we have also discussed the past major bio-sensing efforts through micro/nano cantilevers and about recent progress in the field.
近年来,生物传感研究的新趋势促使科学家和研究专业人员研究开发小型化生物分析器件,使其更便携、无标记且体积更小。随着新的微纳制造技术和表面功能化技术的发展,基于悬臂梁的器件的性能在敏感场级检测的重要领域得到了显著提高。悬臂梁已经从微尺度缩小到纳米尺度,由于这种尺度的变化,它们变得异常灵敏,并且具有一些异常的相关特性。在这篇综述中,我们讨论了悬臂梁操作的基本原理、检测方法,以及通过基于悬臂梁的传感平台的过去、现在和未来的研究方法。除此之外,我们还讨论了过去通过微纳悬臂梁进行的主要生物传感工作以及该领域的最新进展。