Schleinitz N, Briantais A, Ebbo M
Département de médecine interne, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.
Département de médecine interne, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.
Rev Med Interne. 2020 Dec;41(12):814-821. doi: 10.1016/j.revmed.2020.06.015. Epub 2020 Jul 27.
The concept of IgG4-related disease (IgG4-RD) has recently been individualized in the early 2000s, but most of the organ involvements are known since more than 100 years. IgG4-RD is a non-malignant fibroinflammatory disorder, characterized by peculiar immunological and pathological abnormalities, which can affect virtually all organs or tissues. Diagnostic criteria have been proposed and have evolved rapidly, with general or organ specific criteria. An international and multidisciplinary group assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) has recently developed and validated a set of classification criteria called 2019 ACR/EULAR classification criteria for IgG4-related disease. The objective of this review is to discuss the evolution from organ specific and general diagnostic criteria toward the 2019 ACR/EULAR classification criteria, as well as respective benefits and limits of these criteria. The use of the 2019 ACR/EULAR classification criteria will help to better define homogeneous group of IgG4-RD patients in future clinical, epidemiological and basic science research studies on the disease.
IgG4相关疾病（IgG4-RD）的概念在21世纪初才得到明确界定，但大多数器官受累情况早在100多年前就已为人所知。IgG4-RD是一种非恶性纤维炎性疾病，其特征为独特的免疫和病理异常，几乎可累及所有器官或组织。目前已提出诊断标准且发展迅速，包括通用标准和器官特异性标准。由美国风湿病学会（ACR）和欧洲抗风湿病联盟（EULAR）组建的一个国际多学科小组最近制定并验证了一套名为2019 ACR/EULAR IgG4相关疾病分类标准。本综述的目的是探讨从器官特异性和通用诊断标准到2019 ACR/EULAR分类标准的演变，以及这些标准各自的优缺点。2019 ACR/EULAR分类标准的应用将有助于在未来关于该疾病的临床、流行病学和基础科学研究中更好地界定IgG4-RD患者的同质群体。
