Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany.
Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany; Cluster of Excellence Physics of Life, Technische Universität Dresden, 01062 Dresden, Germany.
Semin Cell Dev Biol. 2020 Nov;107:161-169. doi: 10.1016/j.semcdb.2020.07.008. Epub 2020 Jul 27.
The partitioning of cells into groups or 'compartments' separated by straight and sharp boundaries is important for tissue formation in animal development. Cells from neighboring compartments are characterized by distinct fates and functions and their continuous separation at compartment boundaries maintains proper tissue organization. Signaling across compartment boundaries can induce the local expression of morphogens that in turn direct growth and patterning of the surrounding cells. Compartment boundaries play therefore an important role in tissue development. Compartment boundaries were first identified in the early 1970s in the Drosophila wing. Here, we review the role of compartment boundaries in growth and patterning of the developing wing and then discuss the genetic and physical mechanisms underlying cell separation at compartment boundaries in this tissue.
细胞分裂成不同的组或“隔室”，这些隔室由直线和锐利的边界隔开，这对于动物发育中的组织形成非常重要。来自相邻隔室的细胞具有不同的命运和功能，它们在隔室边界处的连续分离可以维持组织的正常结构。信号在隔室边界处的传递可以诱导形态发生素的局部表达，而形态发生素反过来又可以指导周围细胞的生长和模式形成。因此，隔室边界在组织发育中起着重要作用。隔室边界在 20 世纪 70 年代早期在果蝇翅膀中首次被发现。在这里，我们回顾了隔室边界在发育中的翅膀的生长和模式形成中的作用，然后讨论了该组织中隔室边界处细胞分离的遗传和物理机制。
