Division of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Front Immunol. 2020 Jul 7;11:1623. doi: 10.3389/fimmu.2020.01623. eCollection 2020.
Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and are now in a more uncertain situation with this rapidly spreading infection. Frontline healthcare workers are succumbing to the infection in their efforts to save lives. There is an urgency to develop treatments for COVID-19, yet there is limited clinical data on the efficacy of potential drug treatments. Countries worldwide implemented a stay-at-home order to "flatten the curve" and relieve the pressure on the health system, but it is uncertain how this will unfold after the economy reopens. Trehalose, a natural glucose disaccharide, is known to impair viral function through the autophagy system. Here, we propose trehalose as a potential preventative treatment for SARS-CoV-2 infection and transmission.
全球各国已确认了数量惊人的 COVID-19 病例，现在很明显，没有任何一个国家能够幸免于 SARS-CoV-2 感染。卫生系统较弱的资源匮乏国家正在努力应对自身的疫情，而现在这种迅速传播的感染使它们的处境更加不确定。一线医护人员在努力拯救生命的过程中不幸感染了病毒。现在迫切需要开发针对 COVID-19 的治疗方法，但关于潜在药物治疗效果的临床数据有限。全球各国实施了居家令，以“拉平曲线”并缓解卫生系统的压力，但在经济重新开放后，情况会如何发展尚不确定。海藻糖是一种天然葡萄糖二糖，已知它可以通过自噬系统损害病毒功能。在这里，我们提出海藻糖作为预防 SARS-CoV-2 感染和传播的潜在治疗方法。
