Chen Junmin, Chen Jianyong, Lu Jingrong
Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
Evid Based Complement Alternat Med. 2020 Jul 14;2020:5354215. doi: 10.1155/2020/5354215. eCollection 2020.
() is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities. However, the pharmacological effect of and its mechanism of action have not to be systematically elucidated yet. In this study, the druggability for active compounds of was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential drug targets of were identified using PharmMapper database. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed via WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Our findings revealed that has extremely superb druggability with 41 putative identified target genes. GO, KEGG, and network analyses showed that these targets were associated with inflammatory immunoreactions, cancer, and other biological processes. In summary, is predicted to target multiple genes/proteins and pathways that shape a network which can exert systematic pharmacological effects.
（）是一种具有广泛药理活性的重要中药。然而，（）的药理作用及其作用机制尚未得到系统阐明。在本研究中，通过中药系统药理学数据库（TCMSP）评估了（）活性成分的成药性，并使用PharmMapper数据库鉴定了（）的潜在药物靶点。此外，通过WebGestalt进行基因本体论（GO）和京都基因与基因组百科全书（KEGG）通路富集分析。使用Cytoscape构建药物-靶点-通路网络以提供直观视图。我们的研究结果表明，（）具有极佳的成药性，鉴定出41个假定的靶基因。GO、KEGG和网络分析表明，这些靶点与炎症免疫反应、癌症和其他生物学过程相关。总之，预计（）靶向多个基因/蛋白质和通路，形成一个可发挥系统药理作用的网络。
