Systematic Elucidation of the Mechanism of via Network Pharmacology.

() is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities. However, the pharmacological effect of and its mechanism of action have not to be systematically elucidated yet. In this study, the druggability for active compounds of was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential drug targets of were identified using PharmMapper database. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed via WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Our findings revealed that has extremely superb druggability with 41 putative identified target genes. GO, KEGG, and network analyses showed that these targets were associated with inflammatory immunoreactions, cancer, and other biological processes. In summary, is predicted to target multiple genes/proteins and pathways that shape a network which can exert systematic pharmacological effects.