Zhang Yun-Fei, Huang Yue, Ni Yi-Hua, Xu Zheng-Min
Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai, People's Republic of China,
Drug Des Devel Ther. 2019 Apr 4;13:1069-1075. doi: 10.2147/DDDT.S189088. eCollection 2019.
Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out.
In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view.
Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes.
Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects.
香叶醇是一种无环单萜醇，从芳香植物的挥发油中提取。尚未对其作用机制进行系统分析。
在本研究中，通过中药系统药理学数据库（TCMSP）评估香叶醇的成药性，并使用比较毒理基因组学数据库（CTD）鉴定香叶醇的潜在靶点。此外，使用WebGestalt进行基因本体（GO）和京都基因与基因组百科全书（KEGG）通路分析。使用Cytoscape构建药物-靶点-通路网络以提供直观视图。
我们的研究结果表明，香叶醇具有出色的成药性，有38个推定的靶基因。GO、KEGG和网络分析表明，这些靶点与癌症、炎症免疫反应和其他生理过程相关。
预计香叶醇靶向多种蛋白质和通路，形成一个可发挥系统药理作用的网络。
