Wu Ye, Huang Rui, Jin Jin-Mei, Zhang Li-Jun, Zhang Hong, Chen Hong-Zhuan, Chen Li-Li, Luan Xin
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Chem. 2020 Jul 7;8:519. doi: 10.3389/fchem.2020.00519. eCollection 2020.
Anoplin is an amphipathic, α-helical bioactive peptide from wasp venom. In recent years, pharmaceutical and organic chemists discovered that anoplin and its derivatives showed multiple pharmacological activities in antibacterial, antitumor, antifungal, and antimalarial activities. Owing to the simple and unique structure and diverse biological activities, anoplin has attracted considerable research interests. This review highlights the advances in structural modification, biological activities, and the outlook of anoplin in order to provide a basis for new drug design and delivery.
蚁蜂毒肽是一种来自黄蜂毒液的两亲性α螺旋生物活性肽。近年来，药物化学家和有机化学家发现，蚁蜂毒肽及其衍生物在抗菌、抗肿瘤、抗真菌和抗疟活性方面表现出多种药理活性。由于其结构简单独特且生物活性多样，蚁蜂毒肽引起了广泛的研究兴趣。本文综述了蚁蜂毒肽在结构修饰、生物活性方面的研究进展及其前景，为新药设计和递送提供依据。
