Santana Clarissa Helena, Moreira Pamela Rodrigues Reina, Rosolem Mayara Caroline, Vasconcelos Rosemeri de Oliveira
Department of Genetics and Animal Breeding, College of Agricultural and Veterinary Sciences (FCAV/UNESP), Jaboticabal, SP, Brazil.
Department of Veterinary Pathology, Faculty of Agricultural and Veterinary Sciences (FCAV/UNESP), Jaboticabal, SP, Brazil.
Vet Anim Sci. 2016 Oct 15;1-2:4-8. doi: 10.1016/j.vas.2016.10.001. eCollection 2016 Dec.
The inflammatory response may have pro or anti-neoplastic effects in tumors, depending on the histological type and malignancy level of the tumor. This study aimed to evaluate the profile of predominant inflammatory cells by immunohistochemistry in cutaneus squamous cell carcinoma (SCC) of dogs, comparing it with the degree of differentiation of the tumor. Twenty samples of SCC were analyzed. The tumors were histologically classified into two groups, differentiated SCC (SCCd=12) and undifferentiated SCC (SCCu=08). The tumor inflammatory infiltrate was determined by immunohistochemistry, in order to identify macrophages, lymphocytes and plasma cells. The comparison between groups, SCCd and SCCu, was not significant concerning the density of macrophages (P=1.0), T lymphocytes (P=0.335) and plasma cells (P=0.075). However, when comparing the inflammatory infiltrate in each group, the macrophages were the predominant cell type in both groups, a significant difference was found in the SCCd with plasma cells (P<0.0001). In the SCCu the difference occurred with lymphocytes (P<0.05) and plasma cells (P=0.0006). It could be concluded that the presence of inflammation in cases of SCC does not play a role in the differentiation of the neoplasm, since the inflammatory infiltrate was similar in both groups of SCC.
炎症反应在肿瘤中可能具有促肿瘤或抗肿瘤作用，这取决于肿瘤的组织学类型和恶性程度。本研究旨在通过免疫组织化学评估犬皮肤鳞状细胞癌（SCC）中主要炎症细胞的特征，并将其与肿瘤的分化程度进行比较。分析了20个SCC样本。这些肿瘤在组织学上分为两组，分化型SCC（SCCd = 12）和未分化型SCC（SCCu = 08）。通过免疫组织化学确定肿瘤炎症浸润情况，以识别巨噬细胞、淋巴细胞和浆细胞。SCCd组和SCCu组在巨噬细胞密度（P = 1.0）、T淋巴细胞密度（P = 0.335）和浆细胞密度（P = 0.075）方面的比较无显著差异。然而，在比较每组的炎症浸润时，巨噬细胞是两组中的主要细胞类型，在SCCd组中浆细胞存在显著差异（P < 0.0001）。在SCCu组中，淋巴细胞（P < 0.05）和浆细胞（P = 0.0006）存在差异。可以得出结论，SCC病例中的炎症存在在肿瘤分化中不起作用，因为两组SCC的炎症浸润相似。
