Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
IUBMB Life. 2020 Oct;72(10):2065-2079. doi: 10.1002/iub.2350. Epub 2020 Jul 31.
Cancer, even currently, is one of the main reasons for mortality and morbidity, worldwide. In recent years, a great deal of effort has been made to find efficient therapeutic strategies for cancer, however, particularly with regards to side effects and the possibility of complete remission. Berberine (BBR) is a nature-driven phytochemical component originated from different plant groups such as Berberis vulgaris, Berberis aquifolium, and Berberis aristata. BBR is a well-known nutraceutical because of its wide range of pharmacological activities including anti-inflammatory, antidiabetic, antibacterial, antiparasitic, antidiarrheal, antihypertensive, hypolipidemic, and fungicide. In addition, it exhibits inhibitory effects on multiple types of cancers. In this review, we have elaborated on the anticancer effects of BBR through the regulation of different molecular pathways such as: inducing apoptosis, autophagy, arresting cell cycle, and inhibiting metastasis and invasion.
癌症，即使是在目前，仍然是全球范围内死亡和发病的主要原因之一。近年来，人们做出了大量努力来寻找针对癌症的有效治疗策略，然而，这些策略特别关注副作用和完全缓解的可能性。小檗碱（BBR）是一种源于不同植物群的天然植物化学成分，如小檗属植物、小檗属植物和小檗属植物。BBR 是一种众所周知的营养保健品，因为它具有广泛的药理活性，包括抗炎、抗糖尿病、抗菌、抗寄生虫、抗腹泻、降压、降血脂和杀菌剂。此外，它对多种类型的癌症表现出抑制作用。在这篇综述中，我们通过调节不同的分子途径，如诱导细胞凋亡、自噬、细胞周期阻滞以及抑制转移和侵袭，阐述了 BBR 的抗癌作用。
