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青春期抑制后促性腺激素释放激素类似物治疗联合雄激素治疗对跨性别男性青少年血压动态的影响：一项初步研究。

Blood Pressure Dynamics After Pubertal Suppression with Gonadotropin-Releasing Hormone Analogs Followed by Testosterone Treatment in Transgender Male Adolescents: A Pilot Study.

机构信息

Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

LGBT Health. 2020 Aug/Sep;7(6):340-344. doi: 10.1089/lgbt.2020.0026. Epub 2020 Jul 28.

DOI:10.1089/lgbt.2020.0026
PMID:32735503
Abstract

We analyzed blood pressure (BP) changes in transgender male adolescents treated with gonadotropin-releasing hormone analogs (GnRHa) and after adding testosterone treatment. This was a retrospective pilot study. Outcome measures included systolic BP (SBP) and diastolic BP (DBP) before and after GnRHa initiation and after adding testosterone. Fifteen transgender male adolescents received GnRHa. DBP percentiles increased significantly after GnRHa treatment (from 55.9% ± 26.4 to 73.6% ± 9.4,  = 0.019). BP levels did not meet criteria for hypertension. DBP percentiles were restored after adding testosterone. GnRHa may increase DBP in transgender male adolescents, and testosterone treatment may restore it. Further larger studies are indicated.

摘要

我们分析了接受促性腺激素释放激素类似物（GnRHa）治疗和添加睾酮治疗后 transgender 男性青少年的血压（BP）变化。这是一项回顾性的初步研究。主要结局指标包括 GnRHa 治疗前后及添加睾酮治疗后的收缩压（SBP）和舒张压（DBP）。15 名 transgender 男性青少年接受 GnRHa 治疗。治疗后 DBP 百分位数显著升高（从 55.9%±26.4 到 73.6%±9.4， = 0.019）。血压水平未达到高血压标准。添加睾酮后 DBP 百分位数恢复正常。GnRHa 可能会增加 transgender 男性青少年的 DBP，而睾酮治疗可能会恢复其正常水平。需要进一步开展更大规模的研究。

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