Madia Federica, Corvi Raffaella, Worth Andrew, Matys Izabela, Prieto Pilar
European Commission, Joint Research Centre (JRC), Ispra, Italy; former JRC trainee
ALTEX. 2020 Jul 28;37(4):519-531. doi: 10.14573/altex.2005061.
To develop and evaluate scientifically robust and innovative approaches for the safety assessment of chemicals across multiple regulatory sectors, the EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) has started a project to explore how to better use the available information, including that from existing animal studies. The aim is to minimize reliance on in vivo testing to avoid redundancy and to facilitate the integration of novel non-animal methods in the regulatory setting with the ultimate goal of designing sustainable testing strategies. In this thought-starter paper, we present a number of examples to illustrate and trigger further discussions within the scientific and regulatory communities on ways to extrapolate useful information for predicting toxicity from one toxicity endpoint to another or across endpoints based on mechanistic information.
为了开发和评估跨多个监管部门对化学品进行安全评估的科学稳健且创新的方法，欧盟替代动物试验参考实验室（EURL ECVAM）启动了一个项目，以探索如何更好地利用现有信息，包括来自现有动物研究的信息。目的是尽量减少对体内试验的依赖，避免重复，并促进在监管环境中整合新型非动物方法，最终目标是设计可持续的测试策略。在这篇引发思考的论文中，我们给出了一些例子，以说明并引发科学界和监管界就基于机制信息从一个毒性终点推断到另一个毒性终点或跨终点预测毒性的有用信息的方法展开进一步讨论。
