[Immediate and delayed skin reactions against ten groups of antigens in 355 patients with urticaria and angioneurotic edema].

Immediate and delayed skin reactions against ten group of allergens were investigated in 355 patients with urticaria and angioneurotic edema. The wheal and flare reaction were characteristic of the type I-IgE mediated hypersensitivity reaction in human skin. This reaction develops rapidly after injection of antigen, peaking 10-30 minutes, and then subsides within a few hours. However, careful observation for longer periods, has shown that in many instances a late inflammatory response also appears at the same site and is quite different in appearance from the initial reaction. In this study, we have investigated in immediate and also delayed-phase skin reactivity, incidence of the patients.