帕金森病中的小胶质细胞和星形胶质细胞功能障碍。
Microglia and astrocyte dysfunction in parkinson's disease.
机构信息
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Neurobiol Dis. 2020 Oct;144:105028. doi: 10.1016/j.nbd.2020.105028. Epub 2020 Jul 28.
Abstract
While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.
摘要
虽然神经胶质细胞对于调节正常大脑的内环境稳态至关重要，但它们的功能障碍也会导致许多脑部疾病的神经退行性变，包括帕金森病（PD）。最近的研究表明，与 PD 相关的基因在神经胶质细胞以及神经元中表达，并在小胶质细胞和星形胶质细胞中发挥关键作用。在这里，我们讨论了与 PD 相关突变相关的小胶质细胞和星形胶质细胞功能障碍的作用及其在 PD 发病机制中的意义。更好地了解 PD 中小胶质细胞和星形胶质细胞的功能可能有助于深入了解神经退行性变，并为 PD 提供新的治疗方法。
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