循环 microRNAs 对低甲胎蛋白水平乙型肝炎病毒相关肝细胞癌诊断作用的系统评价和荟萃分析。
The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis.
机构信息
Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, China.
Department of Hepatobiliary-Pancreatic Surgery, Third Xiangya Hospital of Central South University, Changsha, 410013, China.
出版信息
BMC Gastroenterol. 2020 Jul 31;20(1):249. doi: 10.1186/s12876-020-01345-5.
BACKGROUND
Alpha-fetoprotein (AFP) has been widely used for many years as a serum marker for hepatocellular carcinoma (HCC). However, AFP has been recognized as having poor sensitivity. More and more studies have concluded that circulating microRNAs (miRNAs) might be a promising biomarker that could complement AFP. However, the diagnostic ability of circulating miRNAs has varied among the studies. Therefore, we performed the present meta-analysis to appraise the diagnostic performance of circulating miRNAs as a biomarker for hepatitis B virus-associated HCC (HBV-HCC) patients with low AFP levels.
METHODS
We performed a systematic review and meta-analysis of the published literature to assess the diagnostic accuracy of circulating miRNAs in differentiating HBV-HCC patients with low AFP levels from non-HCC controls.
RESULTS
Circulating miRNAs showed promising potential in the diagnosis of HBV-HCC patients with low AFP levels. In the low-AFP HBV-HCC patients, the area under the curve (AUC) was 0.88 (95% confidence interval [CI]: 0.84-0.90). The pooled sensitivity and specificity were 0.84 (95% CI: 0.78-0.88) and 0.76 (95% CI: 0.69-0.83), respectively.
CONCLUSIONS
The detection of circulating miRNAs provides a valuable method for the diagnosis of HBV-HCC in patients with low AFP levels.
背景
甲胎蛋白（AFP）多年来一直被广泛用作肝细胞癌（HCC）的血清标志物。然而，AFP 的灵敏度一直被认为较差。越来越多的研究得出结论，循环 microRNAs（miRNAs）可能是一种有前途的生物标志物，可以补充 AFP。然而，循环 miRNAs 的诊断能力在不同的研究中存在差异。因此，我们进行了这项荟萃分析，以评估循环 miRNAs 作为低 AFP 水平的乙型肝炎病毒相关 HCC（HBV-HCC）患者的生物标志物的诊断性能。
方法
我们对已发表的文献进行了系统评价和荟萃分析，以评估循环 miRNAs 在区分低 AFP 水平的 HBV-HCC 患者和非 HCC 对照方面的诊断准确性。
结果
循环 miRNAs 在诊断低 AFP 水平的 HBV-HCC 患者方面显示出有前途的潜力。在低 AFP 的 HBV-HCC 患者中，曲线下面积（AUC）为 0.88（95%置信区间 [CI]：0.84-0.90）。合并的敏感性和特异性分别为 0.84（95%CI：0.78-0.88）和 0.76（95%CI：0.69-0.83）。
结论
循环 miRNAs 的检测为低 AFP 水平的 HBV-HCC 患者的诊断提供了一种有价值的方法。
Zotero 插件