Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Road Jing Wu Wei Qi, Jinan, 250021, Shandong Province, China.
J Orthop Surg Res. 2020 Jul 31;15(1):293. doi: 10.1186/s13018-020-01794-4.
Numerous quantitatively biomechanical studies measuring the fixation stability of femoral stem using micromotions at the bone-implant interfaces in different directions and levels remain inconclusive. This network meta-analysis performed systematically aims to explore the rank probability of micromotions at the bone-implant interfaces based on biomechanical data from studies published.
Two electronic databases, PubMed/MEDLINE and Embase, were utilized to retrieve biomechanical studies providing the data of micromotions at the bone-stem interfaces. After screening and diluting out, the studies that met inclusion criteria will be utilized for statistical analysis. In order to contrast the stability of commonness and differences of the different parts of the femoral stem, the horizontal and vertical comparison of micromotions at the bone-implant interfaces were conducted using the pooled evaluation indexes including the mean difference (MD) and the surface under the cumulative ranking (SUCRA) curve, while inconsistency analysis, sensitivity analysis, subgroup analyses, and publication bias were performed for the stability evaluation of outcomes.
Screening determined that 20 studies involving a total of 249 samples were deemed viable for inclusion in the network meta-analysis. Tip point registered the highest micromotions of 13 measurement points. In the horizontal level, the arrangements of 4 measurement points at the proximal (P1-P4), middle (P5-P8) and distal part of the stem (P9-P12) were P1 = P2 = P3 = P4, P7 > P8 > P6 = P5 and P10 ≥ P12 = P9 = P11, respectively. In the vertical level, the arrangements of 3 measurement points at the anterior, posterior, medial, and lateral directions was P9 > P5 = P1, P10 > P6 > P2, P11 > P7 > P3, and P12 > P8 > P4, respectively.
The network meta-analysis seems to reveal that the distal part of the femoral stem is easier to register higher micromotion, and tip point of femoral stem registers the highest micromotions.
大量使用不同方向和水平的骨-植入物界面微运动来测量股骨柄固定稳定性的定量生物力学研究仍未有定论。本系统综述的网络荟萃分析旨在根据已发表的研究中的生物力学数据,探索基于骨-植入物界面微运动的等级概率。
使用两个电子数据库 PubMed/MEDLINE 和 Embase 检索提供骨-骨界面微运动数据的生物力学研究。筛选和剔除后,将符合纳入标准的研究用于统计分析。为了对比不同股骨柄部分的稳定性和差异,采用平均差 (MD) 和累积排序曲线下面积 (SUCRA) 等汇总评价指标对骨-植入物界面的微运动进行水平和垂直比较,同时对结果的稳定性进行一致性分析、敏感性分析、亚组分析和发表偏倚分析。
筛选确定了 20 项研究,共涉及 249 个样本,符合网络荟萃分析的纳入标准。尖端点的 13 个测量点记录了最高的微运动。在水平方向上,近端(P1-P4)、中间(P5-P8)和远端(P9-P12)部分的 4 个测量点的排列分别为 P1=P2=P3=P4、P7>P8>P6=P5 和 P10≥P12=P9=P11。在垂直方向上,3 个测量点在前、后、内、外方向上的排列分别为 P9>P5=P1、P10>P6>P2、P11>P7>P3 和 P12>P8>P4。
网络荟萃分析似乎表明,股骨柄的远端更容易记录更高的微运动,而股骨柄的尖端点记录了最高的微运动。