Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
World J Microbiol Biotechnol. 2020 Aug 1;36(9):131. doi: 10.1007/s11274-020-02907-1.
Antimicrobial resistance (AMR) is one of the significant clinical challenges and also an emerging area of concern arising from nosocomial infections of ESKAPE pathogens, which has been on the rise in both the developed and developing countries alike. These pathogens/superbugs can undergo rapid mutagenesis, which helps them to generate resistance against antimicrobials in addition to the patient's non-adherence to the antibiotic regimen. Sticking to the idea of a 'one-size-fits-all' approach has led to the inappropriate administration of antibiotics resulting in augmentation of antimicrobial resistance. Antimicrobial peptides (AMPs) are the natural host defense peptides that have gained attention in the field of AMR, and recently, synthetic AMPs are well studied to overcome the drawbacks of natural counterparts. This review deals with the novel techniques utilizing the bacteriolytic activity of natural AMPs. The effective localization of these peptides onto the negatively charged bacterial surface by using nanocarriers and structurally nanoengineered antimicrobial peptide polymers (SNAPPs) owing to its smaller size and better antimicrobial activity is also described here.
抗菌药物耐药性（AMR）是临床面临的重大挑战之一，也是医院获得性感染 ESKAPE 病原体引起的一个新出现的令人关注的领域，在发达国家和发展中国家，这种情况都呈上升趋势。这些病原体/超级细菌可以快速发生突变，这有助于它们产生对抗生素的耐药性，此外，患者也不遵守抗生素治疗方案。坚持“一刀切”的理念导致了抗生素的不当使用，从而加剧了抗菌药物耐药性。抗菌肽（AMPs）是天然的宿主防御肽，在抗菌药物耐药性领域引起了关注，最近，合成抗菌肽也被广泛研究以克服天然对应物的缺点。这篇综述讨论了利用天然抗菌肽的溶菌活性的新技术。还描述了通过使用纳米载体和结构纳米工程抗菌肽聚合物（SNAPPs）将这些肽有效定位到带负电荷的细菌表面，这是由于其较小的尺寸和更好的抗菌活性。
