State Key Laboratory of Food Science and Technology, National Center for Technology Innovation on Fast Biological Detection of Grain Quality and Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
State Key Laboratory of Food Science and Technology, National Center for Technology Innovation on Fast Biological Detection of Grain Quality and Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Food Chem. 2021 Jan 15;335:127657. doi: 10.1016/j.foodchem.2020.127657. Epub 2020 Jul 25.
For the past decades, the synthesis of metal nanoclusters has been a great interest for research, for their unique physicochemical properties and great contributions to the catalytic, electrical and biomedical applications. Protein-templated gold nanoclusters (AuNCs) is a kind of fluorescent nanomaterials with good solubility, excellent stability, biocompatibility, decent quantum yields and active groups (-COOH, -NH) for facilitating modifications. Natural proteins are easily available, commercially affordable, diverse and multitudinous in animals, plants and foods, which provide a template pool for the exploration of AuNCs. This is one of the few reviews of specifically focusing on the natural protein-templated fluorescent AuNCs. The syntheses, properties and applications of different AuNCs were enumerated. Prospects were given on utilizing structure-modified proteins, bioactive enzymes, antibodies which should endow the AuNCs more favourable fluorescence performances and functional characteristics. The applications of AuNCs in analytical, biomedical and food sciences would be further heightened.
在过去的几十年里，金属纳米团簇的合成一直是研究的热点，因为它们具有独特的物理化学性质，并为催化、电气和生物医学应用做出了巨大贡献。蛋白质模板金纳米团簇（AuNCs）是一种荧光纳米材料，具有良好的溶解性、优异的稳定性、生物相容性、适当的量子产率和活性基团（-COOH、-NH），有利于修饰。天然蛋白质在动物、植物和食品中易得、价格合理、种类繁多，为 AuNCs 的探索提供了模板库。这是为数不多的专门关注天然蛋白质模板荧光 AuNCs 的综述之一。列举了不同 AuNCs 的合成、性质和应用。展望了利用结构修饰蛋白、生物活性酶和抗体，赋予 AuNCs 更有利的荧光性能和功能特性。AuNCs 在分析、生物医学和食品科学中的应用将进一步提高。
