轻度新冠肺炎住院青年患者的特征与转归

Characteristics and Outcomes of Hospitalized Young Adults with Mild Covid -19.

作者信息

Sharma Arvind Kumar, Ahmed Asrar, Baig Vaseem Naheed, Dhakar Prahlad, Dalela Gaurav, Kacker Sudhanshu, Panwar Vasim Raja, Panwar Raja Babu, Gupta Rajeev

机构信息

Department of Community Medicine, RUHS College of Medical Sciences, Rajasthan.

Department of Medicine, RUHS College of Medical Sciences, Rajasthan.

出版信息

J Assoc Physicians India. 2020 Aug;68(8):62-65.

DOI:

PMID:32738843

Abstract

BACKGROUND

Stormy course has been reported among hospitalized adults with COVID-19 in high- and middle-income countries. To assess clinical outcomes in consecutively hospitalized patients with mild covid-19 in India we performed a study.

METHODS

We developed a case registry of successive patients admitted with suspected covid-19 infection to our hospital (n=501). Covid-19 was diagnosed using reverse transcriptase polymerase chain reaction (RT-PCR). Demographic, clinical, investigations details and outcomes were recorded. Descriptive statistics are presented.

RESULTS

Covid-19 was diagnosed in 234 (46.7%) and data compared with 267 (53.3%) negative controls. Mean age of covid-19 patients was 35.1±16.6y, 59.4% were <40y and 64% men. Symptoms were in less than 10% and comorbidities were in 4-8%. History of BCG vaccination was in 49% cases vs 10% controls. Cases compared to controls had significantly greater white cell (6.96+1.89 vs 6.12+1.69x109 cells/L) and lower lymphocyte count (1.98+0.79 vs 2.32+0.91x109 cells/L). No radiological and electrocardiographic abnormality was observed. All these were isolated or quarantined in the hospital and observed. Covid-19 patients received hydroxychloroquine and azithromycin according to prevalent guidelines. One patient needed oxygen support while hospital course was uncomplicated in the rest. All were discharged alive. Conversion to virus negative status was in 10.2±6.4 days and was significantly lower in age >40y (9.1±5.2) compared to 40-59y (11.3±6.1) and ≥60y (16.4±13.3) (p=0.001).

CONCLUSIONS

This hospital-based registry shows that mildly symptomatic or asymptomatic young covid-19 patients have excellent prognosis.

摘要

背景

在高收入和中等收入国家，住院的新冠肺炎成年患者病程凶险。为评估印度连续住院的轻症新冠肺炎患者的临床结局，我们开展了一项研究。

方法

我们建立了一个病例登记册，记录我院收治的疑似新冠肺炎感染的连续患者（n = 501）。采用逆转录聚合酶链反应（RT-PCR）诊断新冠肺炎。记录人口统计学、临床、检查细节及结局，并进行描述性统计分析。

结果

234例（46.7%）确诊为新冠肺炎，与267例（53.3%）阴性对照进行数据比较。新冠肺炎患者的平均年龄为35.1±16.6岁，59.4%年龄小于40岁，男性占64%。症状出现率低于10%，合并症发生率为4 - 8%。49%的病例有卡介苗接种史，而对照组为10%。与对照组相比，病例组白细胞计数显著更高（6.96 + 1.89对6.12 + 1.69×10⁹个细胞/L），淋巴细胞计数更低（1.98 + 0.79对2.32 + 0.91×10⁹个细胞/L）。未观察到放射学和心电图异常。所有这些患者均在医院进行隔离观察。新冠肺炎患者根据现行指南接受羟氯喹和阿奇霉素治疗。1例患者需要吸氧支持，其余患者住院过程无并发症。所有患者均存活出院。病毒转阴时间为10.2±6.4天，年龄>40岁者（9.1±5.2天）显著低于40 - 59岁者（11.3±6.1天）和≥60岁者（16.4±13.3天）（p = 0.001）。