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季铵化合物QX 572对麻醉猫的血流动力学影响。III. 与肾上腺素能β-肾上腺素受体阻滞剂的相互作用。

Haemodynamic effects of the quaternary ammonium compound QX 572 in anaesthetized cats. III. Interactions with adrenergic beta-adrenoceptor blockade.

作者信息

Aberg G, Arfwidsson I

出版信息

Acta Pharmacol Toxicol (Copenh). 1979 Feb;44(2):99-102. doi: 10.1111/j.1600-0773.1979.tb02302.x.

DOI:10.1111/j.1600-0773.1979.tb02302.x
PMID:32739
Abstract

The positive cardiac chronotropic effects of the antiarrhythmic compound, QX 572, in anaesthetized cats has been shown mainly to be due to a release of catecholamines from sympathetic nerve-endings. Furthermore, these undesired effects of QX 572 on heart rate were decreased by adrenergic beta blockade in the animals. In the present study it was found that an adrenergic beta-blockade did not reveal any cardiodepressive effects of QX 572, that in the normal animals might have been masked by the effects of the drug-induced catecholamine-release.

摘要

抗心律失常化合物QX 572对麻醉猫的正性变时作用主要被证明是由于交感神经末梢释放儿茶酚胺所致。此外，动物体内的肾上腺素能β受体阻断降低了QX 572对心率的这些不良影响。在本研究中发现，肾上腺素能β受体阻断并未揭示QX 572的任何心脏抑制作用，在正常动物中，这种作用可能被药物诱导的儿茶酚胺释放效应所掩盖。

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