Pandey J P, Blaser M J
Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina.
Exp Clin Immunogenet. 1986;3(1):49-53.
Serum samples from 43 Caucasian subjects convalescing from acute Campylobacter jejuni infection were typed for nine Gm and two Km determinants. The sera were also used to measure IgA, IgG, and IgM classes of antibody to acid-labile surface proteins of C. jejuni by an enzyme-linked immunosorbent assay. A highly significant association (p = 0.004) was found between Km1/Km3 heterozygotes and the level of IgA antibodies. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a humoral response to C. jejuni.
对43名正在从空肠弯曲菌急性感染中康复的白种人受试者的血清样本进行了9种Gm和2种Km决定簇分型。这些血清还通过酶联免疫吸附测定法用于检测针对空肠弯曲菌酸不稳定表面蛋白的IgA、IgG和IgM类抗体。发现Km1/Km3杂合子与IgA抗体水平之间存在高度显著的关联（p = 0.004）。这些结果表明存在互补免疫反应基因，在杂合状态下允许对空肠弯曲菌产生体液反应。
