盘尾丝虫病中的免疫球蛋白κ链同种异型（KM）
Immunoglobulin kappa chain allotypes (KM) in onchocerciasis.
作者信息
Pandey J P, Elson L H, Sutherland S E, Guderian R H, Araujo E, Nutman T B
机构信息
Department of Microbiology, Medical University of South Carolina, Charleston 29425, USA.
出版信息
J Clin Invest. 1995 Dec;96(6):2732-4. doi: 10.1172/JCI118341.
GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups--Afro-Ecuadorians and Amerindians--living in a single restricted geographical area of Ecuador, appear to have different risk factors for acquisition and clinical expression of onchocerciasis, a disease caused by the filarial parasite Onchocerca volvulus. In this study, GM and KM allotypes were determined in 25 Afro-Ecuadorians and 24 Amerindians infected with Onchocerca volvulus (INF) and in putative immune individuals (PI). In Afro-Ecuadorians, the frequency of the homozygous KM 3 phenotype was significantly decreased in INF as compared with the PI group (20 vs. 68%; P= 0.0012), while the frequency of the heterozygous KM 1,3 phenotype was increased in INF as compared with the PI subjects (48 vs. 9%; P= 0.0044). These results suggest that in Afro-Ecuadorians KM 3 is associated with a lower relative risk (resistance), whereas KM 1,3 is associated with an increased risk (susceptibility) of onchocerciasis.
GM和KM同种异型是用于人类群体基因特征分析的有力工具，已被证明在某些传染病的遗传易感性中发挥重要作用。生活在厄瓜多尔一个有限地理区域内的两个不同种族群体——非裔厄瓜多尔人和美洲印第安人——似乎在盘尾丝虫病（一种由丝虫寄生虫盘尾丝虫引起的疾病）的感染和临床表现方面存在不同的风险因素。在本研究中，对25名感染盘尾丝虫的非裔厄瓜多尔人、24名感染盘尾丝虫的美洲印第安人（感染组）以及假定的免疫个体（PI）进行了GM和KM同种异型的测定。在非裔厄瓜多尔人中，与PI组相比，感染组中纯合KM 3表型的频率显著降低（20%对68%；P = 0.0012），而与PI个体相比，感染组中杂合KM 1,3表型的频率增加（48%对9%；P = 0.0044）。这些结果表明，在非裔厄瓜多尔人中，KM 3与较低的相对风险（抗性）相关，而KM 1,3与盘尾丝虫病的风险增加（易感性）相关。
Zotero 插件