Hospital, Tawau, Ministry of Health Malaysia, 67, Peti Surat, Tawau, Sabah, 91007, Malaysia.
Dietetic Programme, Centre for Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia.
JPEN J Parenter Enteral Nutr. 2021 Feb;45(2):277-286. doi: 10.1002/jpen.1987. Epub 2020 Sep 10.
Radiation therapy is the treatment of pelvic cancers, with diarrhea often being the most frequent acute side effect. This study aimed to determine the efficacy of partially hydrolyzed guar gum (PHGG) usage in reducing radiotherapy-induced diarrhea and improving bacterial count, nutrition status, and quality of life (QoL) among cancer patients.
Adult patients undergoing pelvic radiation were recruited and randomly assigned to receive supplementation of either 10 g of PHGG or placebo (maltodextrin) twice daily, 14 days prior and 14 days during pelvic radiation. Diarrhea frequency, fecal samples, nutrition status, and QoL were assessed at baseline and days 14, 28 (2 weeks after pelvic radiation), and 45 (at the completion of pelvic radiation, 2 weeks' postsupplementation).
A total of 30 patients (mean age 56.5 ± 10.8 years, 75% malnourished) participated. The mean of diarrhea frequency in the intervention group (IG) was higher compared with the control group (CG) from days 14 and 28 but reduced at day 45. There was a significant intervention effect after controlling for confounders (ie, baseline diarrhea, age, nutrition status) (P < .05). Bifidobacterium count increased by double among the IG at 14 days of PHGG supplementation, whereas such trend was not observed in the CG.
Supplementation of PHGG potentially increased the bifidobacterial count and seemed to have post-supplementation effects by reducing the frequency of diarrhea upon the completion of pelvic radiation treatment.
放射疗法是治疗盆腔癌症的方法，腹泻通常是最常见的急性副作用。本研究旨在确定部分水解瓜尔胶（PHGG）在减少放射治疗引起的腹泻、改善癌症患者的细菌计数、营养状况和生活质量（QoL）方面的疗效。
招募接受盆腔放射治疗的成年患者，并随机分为两组，分别接受每日两次 10 克 PHGG 或安慰剂（麦芽糊精）补充剂，在盆腔放射治疗前 14 天和治疗期间 14 天。在基线和第 14、28 天（盆腔放射治疗后 2 周）和第 45 天（完成盆腔放射治疗，补充剂后 2 周）评估腹泻频率、粪便样本、营养状况和 QoL。
共有 30 名患者（平均年龄 56.5 ± 10.8 岁，75%营养不良）参与了研究。与对照组（CG）相比，干预组（IG）的腹泻频率从第 14 天和第 28 天开始更高，但在第 45 天减少。在控制混杂因素（即基线腹泻、年龄、营养状况）后，干预效果有显著差异（P <.05）。在 PHGG 补充的第 14 天，IG 中的双歧杆菌计数增加了一倍，而 CG 中没有观察到这种趋势。
PHGG 的补充可能增加双歧杆菌的数量，并在盆腔放射治疗完成后通过减少腹泻的频率显示出补充后的效果。
