Department of Theriogenology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Department of Animal Sciences, University of Florida, Gainesville, FL, USA.
Reprod Domest Anim. 2020 Oct;55(10):1425-1433. doi: 10.1111/rda.13793. Epub 2020 Sep 8.
The objectives of the study were to evaluate haemodynamic changes and their relationships among ipsilateral (IPS) and contralateral (CONT) uterine arteries (UA) during different stages of pregnancy in Bos indicus cows. Multiparous pregnant cows (n = 40) having a gestation length 30.47 ± 0.54 (mean ± SD) days were randomly enrolled and subjected to Doppler ultrasonography sequentially at 1st, 2nd, 4th, 6th and 8th months of gestation. Blood flow indices including diameter of UA (mm), blood flow volume (BFVo, ml/min), blood flow velocity (BFVe, cm/s), time-averaged maximum velocity (TAMV, cm/s), pulsatility index (PI) and resistance index (RI) were recorded. Data were analysed with mixed models using the PROC MIXED procedures, and Pearson correlation coefficients were calculated using the PROC CORR statement in SAS. The final statistical models included the fixed effects of side of UA, gestation month and the interaction between side of UA and gestation month. Results revealed that the mean diameter of the UA (12.13 ± 0.22 vs. 10.09 ± 0.22), BFVo (1236.33 ± 0.55 vs. 770.41 ± 0.55), BFVe (17.18 ± 0.42 vs. 15.58 ± 0.42) and TAMV (17.11 ± 0.44 vs. 15.77 ± 0.44) was higher (p < .05) in IPS as compared to CONT side of the UA in cows. However, PI and RI did not differ between IPS and CON arteries of uterus in cows. A very high and positive correlation (r = .89; p < .05) existed between the diameter of UA and BFVo starting from 1st to 8th months of gestation in IPS as well as CONT sides of UA. Moreover, TAMV was highly and positively correlated (r = .91; p < .05) with BFVe throughout the gestation. In conclusion, these haemodynamic changes in the UA could be used as a valuable validity tool to differentiate the compromised pregnancy in Bos indicus cows.
本研究旨在评估在印度野牛牛只妊娠不同阶段中，同侧（IPS）和对侧（CONT）子宫动脉（UA）的血流动力学变化及其相互关系。将 40 头多胎妊娠奶牛随机分为 5 组，每组 8 头，妊娠时长分别为 30.47 ± 0.54（均值 ± 标准差）天。分别在妊娠第 1、2、4、6 和 8 个月时进行多普勒超声检查，记录 UA 直径（mm）、血流容积（BFVo，ml/min）、血流速度（BFVe，cm/s）、平均时间最大速度（TAMV，cm/s）、搏动指数（PI）和阻力指数（RI）等血流指数。采用混合模型分析数据，使用 SAS 中的 PROC MIXED 程序进行处理，使用 PROC CORR 语句计算 Pearson 相关系数。最终的统计模型包括 UA 侧、妊娠月和 UA 侧与妊娠月交互作用的固定效应。结果表明，与 CONT 侧相比，IPS 侧的 UA 平均直径（12.13 ± 0.22 vs. 10.09 ± 0.22）、BFVo（1236.33 ± 0.55 vs. 770.41 ± 0.55）、BFVe（17.18 ± 0.42 vs. 15.58 ± 0.42）和 TAMV（17.11 ± 0.44 vs. 15.77 ± 0.44）更高（p <.05）。然而，IPS 和 CONT 侧子宫动脉的 PI 和 RI 没有差异。从妊娠第 1 个月到第 8 个月，IPS 和 CONT 侧 UA 的直径与 BFVo 之间存在高度正相关（r =.89；p <.05）。此外，TAMV 与 BFVe 在整个妊娠期高度正相关（r =.91；p <.05）。综上所述，这些 UA 的血流动力学变化可以作为一种有价值的有效性工具，用于区分印度野牛牛只的妊娠是否异常。
