Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan.
Clinical Laboratory, Nippon Medical School Tama Nagayama Hospital, Japan.
Jpn J Infect Dis. 2021 Jan 22;74(1):82-84. doi: 10.7883/yoken.JJID.2020.345. Epub 2020 Aug 1.
In the last decade, methicillin-resistant Staphylococcus aureus (MRSA) has been identified in livestock animals, such as swine, poultry, and veal calves, and has been termed livestock-associated MRSA (LA-MRSA). LA-MRSA sequence type (ST) 398 strains can effectively infect and colonize humans, with subsequent human-to-human transmission in both community and hospital settings. Unlike other countries, LA-MRSA had not been reported in Japanese patients until 2019. However, we recently reported a case of intractable arthritis caused by an LA-MRSA CC398 (ST1232) clone, which is a single-locus variant of ST398, in a patient in Tokyo, Japan, with no animal contact (Nakaminami H, et al. Emerg Infect Dis. 2020; 26: 795-7.). Uniquely, the strain was positive for Panton-Valentine leukocidin. Here, we report the second such case in Japan. To prevent the dissemination of LA-MRSA in the Japanese community, the prevalence of the CC398 MRSA clone should be closely monitored in the future.
在过去十年中，耐甲氧西林金黄色葡萄球菌（MRSA）已在猪、家禽和小牛肉牛等牲畜中被发现，并被称为与牲畜相关的 MRSA（LA-MRSA）。LA-MRSA 序列型（ST）398 株可有效感染和定植人类，并在社区和医院环境中发生人与人之间的传播。与其他国家不同，直到 2019 年，LA-MRSA 才在日本患者中报告。然而，我们最近在日本东京报告了一例由 LA-MRSA CC398（ST1232）克隆引起的难治性关节炎病例，该克隆是 ST398 的单一位点变异体，患者无动物接触（Nakaminami H，等。新发传染病。2020;26:795-7.）。该菌株独特的是对 Panton-Valentine 白细胞毒素呈阳性。在这里，我们报告了日本的第二例此类病例。为了防止 LA-MRSA 在日本社区中的传播，未来应密切监测 CC398 MRSA 克隆的流行情况。
