Aoyama Toru, Tamagawa Hiroshi
Department of Surgery, Yokohama City University.
J Cancer. 2020 Jul 11;11(18):5390-5394. doi: 10.7150/jca.46748. eCollection 2020.
Kampo medicine or Japanese/Chinese traditional herbal medicine has long been used for the treatment of various diseases, mainly in Asian countries. In recent years, Asian investigators have attempted to clarify the mechanism and clinical efficacy of Kampo medicine. This review summarizes the background, current status, and future perspectives of Kampo medicine in the multimodal treatment of gastrointestinal cancer. Regarding the clinical effect of Kampo medicine on postoperative dysfunction after gastrointestinal surgery, several investigators have reported that Daikenchuto (TJ-100) had clinical efficacy after abdominal digestive surgery. The administration of TJ-100 during the immediate postoperative period after esophageal cancer surgery, gastric cancer surgery, and liver cancer surgery appeared to promote early recovery of the postoperative bowel function. Regarding Kampo medicine for chemotherapy-induced adverse effects in gastrointestinal cancer, promising results have been obtained for Hangeshashinto (TJ-14) and Goshajinkigan (TJ-107). The addition of TJ-14 might be associated with an improvement in the duration of chemotherapy-induced oral mucositis, and the addition of TJ-107 might be associated with an improvement in oxaliplatin-induced peripheral neurotoxicity. However, while several clinical trials have shown the positive results of Kampo medication for gastrointestinal cancer treatment, the clinical effects of such medicines have been limited. Further trials to investigate the clinical benefits of Kampo medicine are needed.
汉方医学或日本/中国传统草药医学长期以来一直用于治疗各种疾病，主要在亚洲国家。近年来，亚洲研究人员试图阐明汉方医学的作用机制和临床疗效。本综述总结了汉方医学在胃肠道癌多模式治疗中的背景、现状和未来展望。关于汉方医学对胃肠道手术后功能障碍的临床效果，一些研究人员报告说，大建中汤（TJ-100）在腹部消化手术后具有临床疗效。在食管癌手术、胃癌手术和肝癌手术后的术后即刻给予TJ-100似乎能促进术后肠道功能的早期恢复。关于汉方医学用于胃肠道癌化疗引起的不良反应，对于半夏泻心汤（TJ-14）和五积散（TJ-107）已取得了有前景的结果。添加TJ-14可能与化疗引起的口腔黏膜炎持续时间的改善有关，添加TJ-107可能与奥沙利铂引起的周围神经毒性的改善有关。然而，虽然一些临床试验显示了汉方药物治疗胃肠道癌的积极结果，但此类药物的临床效果有限。需要进一步试验来研究汉方医学的临床益处。
