Peng Xianjing, Li Xintong, Xu Zhengyang, Wang Ling, Cai Wei, Yang Shuai, Liao Weihua, Cheng Xiaoguang
Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
Quant Imaging Med Surg. 2020 Aug;10(8):1590-1601. doi: 10.21037/qims-19-835.
Fatty infiltration, as a result of aging, is an essential biomarker of muscle degeneration. This research aimed to investigate the age-dependent change of fatty degeneration in the paraspinal muscles of healthy Chinese women. This study also explores the effect of body size on fatty infiltration of paraspinal muscles.
Cross-sectional area of paraspinal muscles (CSA) and intermuscular adipose tissue (CSA) were measured at the L3 mid-vertebral level of 516 healthy females, who underwent abdomen quantitative computed tomography (QCT) scans. Subsequently, IMAT% [CSA / (CSA + CSA)] were calculated. The relationship between basic information and measurements was evaluated using Spearman correlations. Comparisons of QCT results among different BMI subgroups in different age groups were analyzed with the Kruskal-Wallis H test and LSD, post-hoc correction. Age-related changes were calculated after the adjustment of height and weight.
The mean CSA of 20-29 years group (n=69) and 70-79 years group (n=25) were 3.00 cm and 11.06 cm, respectively. While the mean CSA of 20-29 years group was 38.46 cm and 70-79 years group was 30.86 cm. The mean IMAT% difference between 20-29 years group and 70-79 years group was -18.55%. Strong, positive non-linear associations were observed between ageing and CSA, along with IMAT% (r=0.656, P<0.01; r=0.714, P<0.01). However, CSA was shown to decrease with age in a weak, negative linear fashion (r=-0.265, P<0.01). Positive relationships between BMI and CSA, CSA, along with IMAT%, were found. Significant differences were observed between obesity and normal BMI subgroup for all variables in three age groups. CSA showed a larger age-related difference compared to CSA.
Fatty infiltration in paraspinal muscles increased with age and BMI, while muscle loss may be associated with aging. The present study provided standardized reference data for the fatty degeneration of paraspinal muscles across the adult lifespan of Chinese females, which will play a critical role in future studies.
由于衰老导致的脂肪浸润是肌肉退化的重要生物标志物。本研究旨在调查健康中国女性椎旁肌脂肪变性的年龄依赖性变化。本研究还探讨了体型对椎旁肌脂肪浸润的影响。
对516名接受腹部定量计算机断层扫描（QCT）的健康女性，在L3椎体水平测量椎旁肌横截面积（CSA）和肌间脂肪组织横截面积（CSA）。随后，计算肌间脂肪组织百分比[CSA /（CSA + CSA）]。使用Spearman相关性评估基本信息与测量值之间的关系。不同年龄组不同BMI亚组的QCT结果比较采用Kruskal-Wallis H检验和LSD事后校正分析。在调整身高和体重后计算与年龄相关的变化。
20-29岁组（n = 69）和70-79岁组（n = 25）的平均CSA分别为3.00平方厘米和11.06平方厘米。而20-29岁组的平均CSA为38.46平方厘米，70-79岁组为30.86平方厘米。20-29岁组与70-79岁组之间的平均肌间脂肪组织百分比差异为-18.55%。在年龄与CSA以及肌间脂肪组织百分比之间观察到强的、正的非线性关联（r = 0.656，P < 0.01；r = 0.714，P < 0.01）。然而，CSA随年龄呈弱的、负的线性下降（r = -0.265，P < 0.01）。发现BMI与CSA、CSA以及肌间脂肪组织百分比之间存在正相关关系。在三个年龄组中，肥胖与正常BMI亚组的所有变量之间均观察到显著差异。与CSA相比，CSA显示出更大的年龄相关差异。
椎旁肌脂肪浸润随年龄和BMI增加，而肌肉量减少可能与衰老有关。本研究为中国女性成年期椎旁肌脂肪变性提供了标准化参考数据，这将在未来研究中发挥关键作用。
