Prediction of Cirrhosis in Patients with Chronic Hepatitis C by Genotype 3.

BACKGROUND

Genotype 3 increases fibrosis in chronic hepatitis C (CHC).

AIM

To evaluate the effect of the hepatitis C virus (HCV) genotype on prevalence and severity of liver disease in CHC.

MATERIALS AND METHODS

Nine hundred and forty-nine individuals with positive anti-HCV from June 2016 to May 2017 were enrolled in the study. We compared biochemical and hematological parameters, HCV RNA load, transient elastography, and ultrasound, in genotype 3 and nongenotype 3 patients. Cirrhosis was diagnosed in patients with liver stiffness measurement (LSM) ≥13 kPa.

RESULTS

Out of 835 CHC patients, overall, genotype 3 had higher LSM (11.3 vs 7.62, = 0.01), higher aspartate aminotransferase (AST) (88.4 vs 68.6, = 0.02), and low platelets (228.4 vs 261, = 0.03) with higher prevalence of cirrhosis (115/415 vs 25/245, = 0.01) than nongenotype 3. However, decompensation rates were not significantly different between two groups (32/115 vs 7/25, = 0.98). The subgroup analysis revealed that cirrhotic genotype 3 had advanced age (50 vs 35, < 0.01), male predominance, and higher AST (74.4 vs 57, = 0.01) as compared to noncirrhotic genotype 3 patients. On multivariate analysis, age and AST values were higher in cirrhotic than noncirrhotic genotype 3 patients.

CONCLUSION

Genotype 3 patients have higher prevalence of cirrhosis and fibrosis compared to nongenotype 3 patients; however, decompensation was not different between two groups.

HOW TO CITE THIS ARTICLE

Gupta T, Aggarwal HK, Goyal S, Prediction of Cirrhosis in Patients with Chronic Hepatitis C by Genotype 3. Euroasian J Hepato-Gastroenterol 2020;10(1):7-10.