Zahid Nida, Ahmed Rashida, Adil Salman, Ather Hammad
Department of Surgery Aga Khan University Karachi Pakistan.
Department of Pathology and Laboratory Medicine Aga Khan University Karachi Pakistan.
IJU Case Rep. 2018 Oct 21;2(1):5-8. doi: 10.1002/iju5.12024. eCollection 2019 Jan.
Non-Hodgkin's lymphomas are a heterogeneous group of malignancies in the lymphoid system and ureteric involvement by non-Hodgkin's lymphoma is very rare.
We present a 37-year-old male, presenting with lower urinary tract symptoms and right flank pain. Initially, he presented with lower urinary tract symptoms without having any evidence of urinary tract infection and was managed for nonspecific cystitis. His ureteral histopathology report indicated a diffused infiltration by malignant lymphoid cells and the final diagnosis revealed diffuse large B-cell lymphoma. His positron-emission tomography scan indicated stage 4 disease with skeletal involvement and he was then treated by rituximab, cyclophosphamide, liposomal doxorubicin, vincristine, and methylprednisolone chemotherapy. Later, he was also diagnosed with central nervous system lymphoma and died during his stay in the hospital.
Primary diffuse large B-cell lymphoma of the ureter is extremely rare; however, it should be considered in the differential diagnosis for patients presenting with obstructive uropathy as its early detection is crucial for diagnostic and therapeutic treatment.
非霍奇金淋巴瘤是淋巴系统中一组异质性恶性肿瘤，非霍奇金淋巴瘤累及输尿管非常罕见。
我们报告一名37岁男性，表现为下尿路症状和右侧腰痛。最初，他表现为下尿路症状，无任何尿路感染证据，被诊断为非特异性膀胱炎。他的输尿管组织病理学报告显示恶性淋巴细胞弥漫浸润，最终诊断为弥漫性大B细胞淋巴瘤。他的正电子发射断层扫描显示为4期疾病，伴有骨骼受累，随后接受了利妥昔单抗、环磷酰胺、脂质体阿霉素、长春新碱和甲基强的松龙化疗。后来，他还被诊断出患有中枢神经系统淋巴瘤，并在住院期间死亡。
原发性输尿管弥漫性大B细胞淋巴瘤极为罕见；然而，对于出现梗阻性尿路病的患者，在鉴别诊断中应考虑到该病，因为其早期发现对诊断和治疗至关重要。
