Ren Mengwei, Liu Yanli
Department of Hematology and Oncology, the Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia General Forestry Hospital, No. 81, Lincheng Road, Yakeshi, Hulunbuir, 022150, Inner Mongolia Autonomous Region, China.
Department of Medical Network Service, the Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia General Forestry Hospital, Yakeshi, Inner Mongolia Autonomous Region, China.
J Med Case Rep. 2021 Nov 3;15(1):546. doi: 10.1186/s13256-021-03143-3.
Primary lymphoma of the prostate is an exceedingly rare disease, with diffuse large B-cell lymphoma being the most common known subtype in a small number of reported cases. Due to its low prevalence, there has been a chronic lack of targeted diagnostic guidelines and treatment procedures.
In this article, we report a case of primary diffuse large B-cell lymphoma of the prostate in a 70-year-old Asian man who presented with symptoms of urinary tract obstruction. Histological and immunocytochemical studies of transurethral biopsy of the prostate showed diffuse large B-cell lymphoma. The patient was managed by a combination of eight courses of chemotherapy with a regimen including rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and radiotherapy. Post-chemotherapy computed tomography scans showed complete remission. He remained disease free, until now, 15 months after the end of therapy. We also reviewed and analyzed relevant literature to illustrate the diagnosis, treatment, and prognosis of this disease.
Diffuse large B-cell non-Hodgkin's lymphoma originating in the prostate is a rare and highly aggressive disease that lacks specificity in its clinical presentation and is easily misdiagnosed. This disease should be considered clinically in patients with significant prostate enlargement and insignificant prostate-specific antigen elevation. The diagnosis can be clarified with a prostate puncture biopsy. Chemotherapy is the main treatment for patients and may be supplemented with surgical treatment and radiotherapy.
前列腺原发性淋巴瘤是一种极为罕见的疾病，在少数已报道病例中，弥漫性大B细胞淋巴瘤是最常见的已知亚型。由于其发病率低，长期缺乏针对性的诊断指南和治疗程序。
在本文中，我们报告了一例70岁亚洲男性的前列腺原发性弥漫性大B细胞淋巴瘤病例，该患者表现为尿路梗阻症状。前列腺经尿道活检的组织学和免疫细胞化学研究显示为弥漫性大B细胞淋巴瘤。该患者接受了包括利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松的方案进行的八个疗程化疗与放疗相结合的治疗。化疗后计算机断层扫描显示完全缓解。截至目前，在治疗结束15个月后，他仍无疾病复发。我们还回顾并分析了相关文献，以阐明该疾病的诊断、治疗和预后。
起源于前列腺的弥漫性大B细胞非霍奇金淋巴瘤是一种罕见且侵袭性很强的疾病，其临床表现缺乏特异性，容易误诊。对于前列腺明显肿大且前列腺特异性抗原升高不明显的患者，临床上应考虑该病。通过前列腺穿刺活检可明确诊断。化疗是患者的主要治疗方法，可能辅以手术治疗和放疗。
